Preferred Label : pan-RAF Inhibitor TR128;
NCIt definition : An orally bioavailable small molecule inhibitor of all members of the serine/threonine
protein kinase Raf family, including A-Raf, B-Raf and C-Raf protein kinases, with
potential antineoplastic activity. Upon oral administration, pan-RAF inhibitor TR128
binds to and inhibits the activity of Raf, including the BRAF V600E mutation. This
prevents the activation of Raf-mediated signal transduction pathways, which may inhibit
tumor cell growth. Raf protein kinases are critical enzymes in the Ras/Raf/MEK/ERK
signaling pathway and are upregulated in a variety of cancer cell types. They play
key roles in tumor cell proliferation and survival.;
Molecule name : TR 128; TR-128;
NCI Metathesaurus CUI : CL1907095;
Origin ID : C200276;
UMLS CUI : C5854507;
Semantic type(s)
- concept_is_in_subset
- has_target
