Pan-RAF Inhibitor LY3009120

Preferred Label : Pan-RAF Inhibitor LY3009120;

NCIt related terms : LY-3009120;

NCIt definition : An orally available inhibitor of all members of the serine/threonine protein kinase Raf family, including A-Raf, B-Raf and C-Raf protein kinases, with potential antineoplastic activity. Upon administration, pan-RAF kinase inhibitor LY3009120 inhibits Raf-mediated signal transduction pathways, which may inhibit tumor cell growth. Raf protein kinases play a key role in the RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) signaling pathway, which is often dysregulated in human cancers and plays a key role in tumor cell proliferation and survival.;

UNII : 1GDT36RARO;

InChIKey : HHCBMISMPSAZBF-UHFFFAOYSA-N;

CAS number : 1454682-72-4;

Molecule name : DP-4978; LY-3009120;

Details

Origin ID

C116861;

UMLS CUI

C3896821;

Currated CISMeF NLP mapping
- LY3009120 [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- LY3009120 [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- RAF Proto-Oncogene Serine/Threonine-Protein Kinase [NCIt concept]
- Serine/Threonine-Protein Kinase A-Raf [NCIt concept]
- Serine/Threonine-Protein Kinase B-Raf [NCIt concept]

Keyword's position in hierarchy(ies) :

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