Insulin - CISMeF

Preferred Label : Insulin;

NCIt synonyms : INS;

NCIt definition : Insulin (51 aa, 6 kDa) is encoded by the human INS gene. This protein is involved in the direct regulation of glucose metabolism.;

Alternative definition : CDISC: An antigen encoded by the INS gene and regulates glucose metabolism. It can be considered as an autoantigen and is commonly associated with autoimmune diabetes mellitus.;

NCIt note : Binding of insulin to its receptor stimulates glucose uptake, accelerates both glycolysis and the pentose phosphate cycle and increases glycogen synthesis in the liver. Insulin regulates protein and lipid metabolism. It also decreases blood glucose concentration by shuttling molecules into cells to be used for energy.; Insulin is a cytosolic protein consisting of heterodimer of disulfide-linked alpha and beta chains generated after proteolytic release of an internal fragment, C-peptide, from proinsulin. This protein is produced in pancreatic islet beta cells.;

NCI Metathesaurus CUI : CL026873;

Codes from synonyms : CDR0000046187;

Details

Origin ID

C2271;

UMLS CUI

C4721402;

Automatic exact mappings (from CISMeF team)
- Bound insulin (substance) [SNOMED CT concept]
- Hyperinsulinaemia [MedDRA Preferred Term]
- Infantile nystagmus syndrome (disorder) [SNOMED CT concept]
- Insular structure (body structure) [SNOMED CT concept]
- Insulin [OMIM gene]
- Insulin (amorphous) (globin) (isophane) (Lente) (NPH) (Semilente) (Ultralente) [ICD-11 Extension code]
- Insulin regular [LOINC component]
- Insulin used (attribute) [SNOMED CT concept]
- diabetes medicines [MedlinePlus Topic]
- insulin [HGNC gene]
- insulin [LOINC Challenge]
- insulin [Artificial nutrition thesaurus concept]
- insulin [EMDN type]
- insulin [medical devices type]
False automatic mappings
- Insulin (substance) [SNOMED CT concept]
- obsolete insulin [GO term]
OMIM relation
- Insulin [OMIM Phenotype]
See also inter- (CISMeF)
- Product containing insulin (product) [SNOMED CT concept]
- insulin (beef) [ATC Code]
- insulin (beef) [ATC Code]
- insulin (beef) [ATC Code]
- insulin (beef) [ATC Code]
- insulin (human) [ATC Code]
- insulin (human) [ATC Code]
- insulin (human) [ATC Code]
- insulin (human) [ATC Code]
- insulin (pork) [ATC Code]
- insulin (pork) [ATC Code]
- insulin (pork) [ATC Code]
- insulin (pork) [ATC Code]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Hormone [UMLS semantic type]
UMLS correspondences (same concept)
- Insulin [FMA entity]
- Insulin [LOINC component]
- Insulin (substance) [SNOMED CT concept]
- Insulin regular [LOINC component]
- Product containing insulin (product) [SNOMED CT concept]
- Regular insulin (substance) [SNOMED CT concept]
- insulin [Substance BNPC]
- insulin [MeSH concept]
- insulin [SNOMED Notion]
- insulin [MeSH Descriptor]
- insulin preparation, nos [SNOMED Notion]
Validated automatic mappings to BTNT
- insulin (human) [Substance BNPC]
- insulin (human) [ATC Code]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
gene_encodes_gene_product
- INS Gene [NCIt concept]
- Peptide Hormone Gene [NCIt concept]
gene_product_expressed_in_tissue
- Islet of Langerhans [NCIt concept]
gene_product_is_element_in_pathway
- Alzheimer's Disease Pathway KEGG [NCIt concept]
- Dentatorubropallidoluysian Atrophy (DRPLA) Pathway [NCIt concept]
- Growth Hormone Signaling Pathway [NCIt concept]
- Insulin Signaling Pathway [NCIt concept]
- PPAR-alpha Gene Regulation Pathway [NCIt concept]
- Parkinson's Disease Pathway KEGG [NCIt concept]
- Skeletal Myogenesis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Energy Metabolism Process [NCIt concept]
- Glycolysis [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Lipid Metabolic Process [NCIt concept]
- Protein Metabolism Process [NCIt concept]
- Transport Process [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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