Preferred Label : Insulin;
Obsolete resource : true;
Alternative titles and symbols : Ins; Proinsulinhyperproinsulinemia; Ins-igf2 spliced read-through transcripts; Insigf;
Description : Insulin, synthesized by the beta cells of the islets of Langerhans, consists of 2
dissimilar polypeptide chains, A and B, which are linked by 2 disulfide bonds. However,
unlike many other proteins, e.g., hemoglobin, made up of structurally distinct subunits,
insulin is under the control of a single genetic locus; chains A and B are derived
from a 1-chain precursor, proinsulin, which was discovered by Steiner and Oyer (1967).
Proinsulin is converted to insulin by the enzymatic removal of a segment that connects
the amino end of the A chain to the carboxyl end of the B chain. This segment is called
the C (for 'connecting') peptide.;
Origin ID : 176730;
UMLS CUI : C1337112;
Automatic exact mappings (from CISMeF team)
- False automatic mappings
- NCIt concept(s)
- ORDO concept(s)
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to NTBT
