Thymosin Beta-4

Preferred Label : Thymosin Beta-4;

NCIt synonyms : TMSB4X; Fx; Prothymosin Beta-4; T Beta-4;

NCIt definition : Thymosin beta-4 (44 aa, 5 kDa) is encoded by the human TMSB4X gene. This protein plays a role in the downregulation of actin polymerization.;

NCIt note : Thymosin beta-4 is cleaved to release a biologically active tetrapeptide consisting of amino acids 2-5, which is called hematopoietic system regulatory peptide and the synthetic acetylated peptide is called seraspenide. Seraspenide causes G1 phase arrest for hematopoietic stem cells.; Thymosin beta-4 and thymosin beta-4, Y-chromosomal are identical except for amino acid positions 6, 30 and 39.;

Details

Origin ID

C137963;

UMLS CUI

C4521323;

Automatic exact mappings (from CISMeF team)
- Gdp-L-fucose synthase [OMIM gene]
- Thymosin, beta-4, X chromosome [OMIM gene]
- thymosin beta(4) [MeSH Supplementary Concept]
- thymosin beta(4) [MeSH concept]
OMIM relation
- Thymosin, beta-4, X chromosome [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- Cytoskeletal Gene [NCIt concept]
- Structural Protein Gene [NCIt concept]
- TMSB4X Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoskeleton [NCIt concept]
gene_product_has_biochemical_function
- Actin-Binding Protein [NCIt concept]
- Thymosin Family [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Movement Process [NCIt concept]
- Cellular Migration Process [NCIt concept]
- Cytoskeletal Modeling [NCIt concept]
- Cytoskeletal Process [NCIt concept]
- Regulation of Cell Shape [NCIt concept]

Keyword's position in hierarchy(ies) :

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