LLGL1 wt Allele

Preferred Label : LLGL1 wt Allele;

NCIt synonyms : HUGL; HUGL-1; DLG4; Lethal Giant Larvae Homolog 1 (Drosophila) wt Allele; HUGL1; LLGL;

NCIt definition : Human LLGL1 wild-type allele is located in the vicinity of 17p11.2 and is approximately 19 kb in length. This allele, which encodes lethal(2) giant larvae protein homolog 1 protein, plays a role in the regulation of mitotic spindle orientation, cell proliferation, neuroepithelial cell differentiation, tumor suppression and cytoskeletal maintenance. Aberrant expression of the gene is associated with the progression of both colorectal cancers and melanoma.;

GenBank Accession Number : NM_004140;

Details

Origin ID

C91767;

UMLS CUI

C2984546;

OMIM relation
- Llgl scribble cell polarity complex component 1 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 17p11.2 [NCIt concept]
gene_is_element_in_pathway
- Tight Junction Assembly Pathway [NCIt concept]
gene_plays_role_in_process
- Cell Movement Process [NCIt concept]
- Cytoskeletal Modeling [NCIt concept]
- Cytoskeletal Process [NCIt concept]
- Exocytosis [NCIt concept]
- Regulation of Cell Shape [NCIt concept]

Keyword's position in hierarchy(ies) :

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