GLI2 wt Allele

Preferred Label : GLI2 wt Allele;

NCIt synonyms : THP; GLI Family Zinc Finger 2 wt Allele; GLI2; HPE9; THP2; PHS2; THP1; GLI-Kruppel Family Member 2 Gene; GLI-Kruppel Family Member GLI2 Gene; CJS; Glioma-Associated Oncogene Family Zinc Finger 2 Gene;

NCIt definition : Human GLI2 wild-type allele is located in the vicinity of 2q14 and is approximately 200 kb in length. This allele, which encodes zinc finger protein GLI2, is involved in the modulation of transcription by RNA polymerase II.;

NCIt note : The GLI2 gene product binds to the DNA sequence 5'-GAACCACCCA-3', participates in the enhancement of transcription of human T-cell leukemia virus type 1, and may play a role during both embryogenesis and sonic hedgehog signal transduction (GeneCards).;

GenBank Accession Number : NM_005270; M20672;

Details

Origin ID

C52924;

UMLS CUI

C1705396;

Currated CISMeF NLP mapping
- THP(A) [MeSH concept]
OMIM relation
- Gli-kruppel family member 2 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_associated_with_disease
- Skin Basal Cell Carcinoma [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 2: 121266089-121465186 [NCIt concept]
gene_in_chromosomal_location
- 2q14 [NCIt concept]
gene_is_element_in_pathway
- Basal Cell Carcinoma Pathway [NCIt concept]
- Hedgehog Family-Mediated Signaling Pathway [NCIt concept]
- Hedgehog Signaling Events Mediated by Gli Family Proteins [NCIt concept]
- Hedgehog Signaling Pathway [NCIt concept]
- Sonic Hedgehog Pathway [NCIt concept]
gene_plays_role_in_process
- DNA Binding [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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