Preferred Label : LATS1 wt Allele;
NCIt synonyms : WTS; WARTS; LATS, Large Tumor Suppressor, Homolog 1 Gene; LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) Gene; LATS (Large Tumor Suppressor, Drosophila) Homolog 1 Gene; LATS, Large Tumor Suppressor, Drosophila, Homolog of, 1 Gene; Large Tumor Suppressor Kinase 1 wt Allele;
NCIt definition : Human LATS1 wild-type allele is located within 6q24-q25.1 and is approximately 108
kb in length. This allele, which encodes serine/threonine-protein kinase LATS1 protein,
plays a role in cell cycle regulation and cytokinesis. Down-regulation of LATS1 gene
expression by promoter hypermethylation is associated with an aggressive phenotype
in breast cancer.;
NCIt note : The LATS1 gene is widely expressed in both fetal and adult tissues. Serine/threonine-protein
kinase LATS1 protein is a tumor suppressor protein that functions to maintain ploidy
by means of its action at the G1 tetraploidy checkpoint, negative regulation of the
G2/M transition and inhibition of mitotic progression. This protein also regulates
expression of the TP53 tumor suppressor gene.;
GenBank Accession Number : NM_004690;
Origin ID : C51210;
UMLS CUI : C1705714;
Currated CISMeF NLP mapping
- warts [MedlinePlus Topic]
False automatic mappings
OMIM relation
Semantic type(s)
concept_is_in_subset
gene_found_in_organism
gene_has_physical_location
gene_in_chromosomal_location
gene_plays_role_in_process
https://www.canada.ca/fr/sante-publique/services/maladies-infectieuses/sante-sexuelle-infections-transmissibles-sexuellement/lignes-directrices-canadiennes/verrues-anogenitales.html
2024
Canada
guideline
LATS1 wt Allele
warts
papillomaviridae
warts
condylomata acuminata
Human Papillomavirus Viruses
KMT2A wt Allele
human papillomavirus, nos
condyloma acuminatum
Human Papillomavirus
---