LATS1 wt Allele

Preferred Label : LATS1 wt Allele;

NCIt synonyms : WTS; WARTS; LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) wt Allele;

NCIt definition : Human LATS1 wild-type allele is located within 6q24-q25.1 and is approximately 108 kb in length. This allele, which encodes serine/threonine-protein kinase LATS1 protein, plays a role in cell cycle regulation and cytokinesis. Down-regulation of LATS1 gene expression by promoter hypermethylation is associated with an aggressive phenotype in breast cancer.;

NCIt note : The LATS1 gene is widely expressed in both fetal and adult tissues. Serine/threonine-protein kinase LATS1 protein is a tumor suppressor protein that functions to maintain ploidy by means of its action at the G1 tetraploidy checkpoint, negative regulation of the G2/M transition and inhibition of mitotic progression. This protein also regulates expression of the TP53 tumor suppressor gene.;

GenBank Accession Number : NM_004690;

Details

Origin ID

C51210;

UMLS CUI

C1705714;

Currated CISMeF NLP mapping
- Verruca (morphologic abnormality) [SNOMED CT concept]
- Verruca vulgaris (disorder) [SNOMED CT concept]
- Verrucae [HPO term]
- Wart [PASCAL descriptor]
- Wart [ICNP subject]
- Wart [MedDRA LLT]
- Wart (viral) [MedDRA LLT]
- Warts [MedDRA LLT]
- Warts (viral) [MedDRA LLT]
- wart [Radlex concept]
- warts [ICPC-2 Rubric]
- warts [MedlinePlus Topic]
- warts [MeSH Descriptor]
- warts [MeSH concept]
False automatic mappings
- verruca vulgaris [Disease (Nov.)]
OMIM relation
- Large tumor suppressor kinase 1 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 6: 150131506-150023744 [NCIt concept]
gene_in_chromosomal_location
- 6q24-q25.1 [NCIt concept]
gene_plays_role_in_process
- Cell Cycle Regulation Process [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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