TEAD Transcription Factor Family

Preferred Label : TEAD Transcription Factor Family;

NCIt synonyms : TEA Domain Family; TEAD Family; TEA Domain Transcription Factor Family; TEA Domain Transcription Factor; TEAD Transcription Factor;

NCIt definition : A family of transcription factors that play important roles during development, cell proliferation, regeneration, and tissue homeostasis as members of various signal transduction pathways including Hippo, Wnt, transforming growth factor beta (TGFB), and epidermal growth factor receptor (EGFR) pathways. Members of the family have an N-terminal DNA-binding region of about 66 to 68 amino acids, which is named for the two proteins that originally defined the domain: TEF-1 and abaA (TEA domain or TEAD), and a C-terminal region YAP binding domain (YBD) that binds to the transcriptional coactivators of the Hippo signaling pathway, YAP1 and WWTR1(TAZ).;

NCIt note : There are four human TEAD transcription factors.;

NCI Metathesaurus CUI : CL1792183;

Details

Origin ID

C187385;

UMLS CUI

C5544498;

Automatic exact mappings (from CISMeF team)
- TEA Domain Transcription Factors [MeSH concept]
Biochemical function of gene products
- Transcriptional Enhancer Factor TEF-3 [NCIt concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- TEA Domain Transcription Factors [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_product_has_biochemical_function
- Transcription Factor [NCIt concept]
gene_product_plays_role_in_biological_process
- Signal Transduction [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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