" /> Serine/Threonine-Protein Kinase LATS1 - CISMeF





Preferred Label : Serine/Threonine-Protein Kinase LATS1;

NCIt synonyms : Large Tumor Suppressor Kinase 1; Large Tumor Suppressor 1; LATS1; LATS1 Protein; LATS Homolog 1; WARTS Protein Kinase; Large Tumor Suppressor Homolog 1; h-warts; EC 2.7.11.1; Large Tumor Suppressor Homolog-1 Protein;

NCIt definition : Serine/threonine-protein kinase LATS1 (1130 aa, 127 kDa) is encoded by the human LATS1 gene. This protein plays a role in both mitosis and serine/threonine phosphorylation.;

NCIt note : LATS1 is a negative regulator of CDC2/cyclin A. In early mitosis, it complexes (via the N-terminal region) with the mitotic apparatus cell cycle controller CDC2 kinase; the complex shows reduced H1 histone kinase activity.;

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04/05/2025


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