Serine/Threonine-Protein Kinase LATS1

Preferred Label : Serine/Threonine-Protein Kinase LATS1;

NCIt synonyms : LATS (Large Tumor Suppressor) Homolog 1; Large Tumor Suppressor 1; LATS1; LATS1 Protein; LATS Homolog 1; WARTS Protein Kinase; Large Tumor Suppressor Homolog 1; h-warts; EC 2.7.11.1; Large Tumor Suppressor Homolog-1 Protein;

NCIt definition : Serine/threonine-protein kinase LATS1 (1130 aa, 127 kDa) is encoded by the human LATS1 gene. This protein plays a role in both mitosis and serine/threonine phosphorylation.;

NCIt note : LATS1 is a negative regulator of CDC2/cyclin A. In early mitosis, it complexes (via the N-terminal region) with the mitotic apparatus cell cycle controller CDC2 kinase; the complex shows reduced H1 histone kinase activity.;

Details

Origin ID

C26344;

UMLS CUI

C1259016;

OMIM relation
- Large tumor suppressor kinase 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- LATS1 protein, human [MeSH Supplementary Concept]
- LATS1 protein, human [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- LATS1 Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
- UBA Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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