Histone Acetyltransferase KAT5

Preferred Label : Histone Acetyltransferase KAT5;

NCIt synonyms : cPLA2 Interacting Protein; TAT Interacting Protein 60; HIV-1 Tat Interactive Protein, 60kDa; HTATIP; Histone Acetyltransferase HTATIP; HIV-1 Tat Interactive Protein; EC 2.3.1.48; cPLA(2)-Interacting Protein; TIP60; 60 kDa Tat-Interactive Protein; Lysine Acetyltransferase 5;

NCIt definition : Histone acetyltransferase KAT5 (513 aa, 59 kDa) is encoded by the human KAT5 gene. This protein is involved in DNA damage response, histone acetylation and transcriptional activation.;

NCIt note : TIP60 interacts with the activation domain of Tat, an activator of HIV gene expression. The yeast SAS2 transcriptional silencing protein, important for exit from the cell cycle, is closely related to TIP60. The widely expressed cell surface amyloid-beta precursor protein is cleaved by gamma-secretase and its cytoplasmic tail forms a multimeric complex with the nuclear adaptor protein FE65 and the histone acetyltransferase TIP60. This complex potently stimulates transcription. (from OMIM);

Details

Origin ID

C19887;

UMLS CUI

C1336632;

Currated CISMeF NLP mapping
- KAT5 protein, human [MeSH concept]
- KAT5 protein, human [MeSH Supplementary Concept]
OMIM relation
- Lysine acetyltransferase 5 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- KAT5 protein, human [MeSH concept]
- KAT5 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- KAT5 Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- ATF-2 Transcription Factor Signaling Pathway [NCIt concept]
- Androgen Receptor Regulation Pathway [NCIt concept]
- Pitx2 Transcription Regulation Pathway [NCIt concept]
- p53 Pathway for Transcriptional Regulation [NCIt concept]
gene_product_plays_role_in_biological_process
- Chromatin Remodeling [NCIt concept]
- DNA Repair [NCIt concept]
- Histone Acetylation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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