Transformation/Transcription Domain-Associated Protein

Preferred Label : Transformation/Transcription Domain-Associated Protein;

NCIt synonyms : 350/400 kDa PCAF-Associated Factor; TRRAP; Transformation-Transcription Domain-Associated Protein; STAF40; PAF350/400; TRA1 Homolog;

NCIt definition : Transformation/transcription domain-associated protein (3859 aa, 438 kDa) is encoded by the human TRRAP gene. This protein plays a role in the mediation of both protein-protein interactions and histone acetylation.;

NCIt note : Transformation/transcription domain-associated protein is a component of the multiprotein chromatin PCAF histone acetylase complex, TFTC-HAT complex, STAGA complex, and TIP60 HAT and BAF53 complexes, each of which acetylates histone H4/H2A in nucleosomes. TRRAP is required for p53-, E2F1- and E2F4-mediated transcription activation, interacts with GCN5L2, TP53, MYC, E2F1, and E2F4 transcription factors, and it may link E1A, MYC, and E2F1 to HAT complexes to allow transcription activation.;

Details

Origin ID

C30132;

UMLS CUI

C1336800;

Currated CISMeF NLP mapping
- transformation-transcription domain-associated protein [MeSH concept]
- transformation-transcription domain-associated protein [MeSH Supplementary Concept]
OMIM relation
- Transformation/transcription domain-associated protein [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- TRRAP protein, human [MeSH concept]
gene_encodes_gene_product
- Regulatory Gene [NCIt concept]
- TRRAP Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_biochemical_function
- Chromatin Remodeling Factor [NCIt concept]
- Transcription Coactivator [NCIt concept]
gene_product_is_element_in_pathway
- E2F Transcription Factor Pathway [NCIt concept]
- Pitx2 Transcription Regulation Pathway [NCIt concept]
- p53 Effector Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- Chromatin Remodeling [NCIt concept]
- Transcriptional Activation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients