Alpha-2-Antiplasmin

Preferred Label : Alpha-2-Antiplasmin;

NCIt synonyms : Serpin F2; Alpha-2-AP; ALPHA-2-PI; Alpha-2-Plasmin Inhibitor; SERPINF2;

NCIt definition : Alpha-2-antiplasmin (491 aa, 55 kDa) is encoded by the human SERPINF2 gene. This protein plays a role in the regulation of plasmin-mediated processes during blood coagulation.;

NCIt note : Alpha-2-antiplasmin primarily targets plasmin and trypsin, but it also inhibits matriptase-3 (transmembrane protease serine 7; TMPRSS7) and chymotrypsin. (UniProt);

Details

Origin ID

C129263;

UMLS CUI

C2713682;

Automatic exact mappings (from CISMeF team)
- Serpin peptidase inhibitor, clade f, member 2 [OMIM gene]
- alpha-2-antiplasmin [Blood Transfusion thesaurus concept]
- serpin family F member 2 [ORDO Gene]
- serpin family F member 2 [HGNC gene]
Currated CISMeF NLP mapping
- Alpha 2 antiplasmin [MedDRA LLT]
- Antiplasmin (substance) [SNOMED CT concept]
- Plasmin inhibitor [LOINC component]
- alpha-2 plasmin inhibitor [SNOMED Notion]
- alpha-2-Antiplasmin [MeSH Descriptor]
- alpha-2-Antiplasmin [MeSH concept]
- antiplasmin [SNOMED Notion]
OMIM relation
- Serpin peptidase inhibitor, clade f, member 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- SERPINF2 protein, human [MeSH Supplementary Concept]
- SERPINF2 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Inhibitor Gene [NCIt concept]
- Proteinase Inhibitor Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- SERPINA3 Gene [NCIt concept]
- SERPINF2 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Serpin [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- Complement and Coagulation Cascade [NCIt concept]
gene_product_plays_role_in_biological_process
- Enzyme Inhibition [NCIt concept]
- Regulation of Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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