Antithrombin-III

Preferred Label : Antithrombin-III;

NCIt synonyms : Serine-Cysteine Proteinase Inhibitor Clade C Member 1; SERPINC1; Serpin C1; ATIII; Antithrombin III;

NCIt definition : Antithrombin-III (464 aa, 53 kDa) is encoded by the human SERPINC1 gene. This protein is involved in the negative regulation of serine proteinase activity during blood coagulation.;

NCIt note : Antithrombin-III can inhibit thrombin, matriptase-3/TMPRSS7, and coagulation factors IXa, Xa and Xia. (UniProt);

NCI Metathesaurus CUI : CL360008;

Details

Origin ID

C104683;

UMLS CUI

C2717481;

Automatic exact mappings (from CISMeF team)
- Serpin peptidase inhibitor, clade C (antithrombin), member 1 [OMIM gene]
- antithrombin I [MeSH concept]
- antithrombin-III [OBI concept]
- fibrin [MeSH Descriptor]
- serpin family C member 1 [ORDO Gene]
- serpin family C member 1 [HGNC gene]
Currated CISMeF NLP mapping
- Antithrombin [LOINC component]
- Antithrombin III [ICD-11 Extension code]
- Antithrombin III [SMS substance]
- Antithrombin III (substance) [SNOMED CT concept]
- Human antithrombin III (substance) [SNOMED CT concept]
- antithrombin [Substance BNPC]
- antithrombin III [MeSH Descriptor]
- antithrombin III [MeSH concept]
- antithrombin III [Blood Transfusion thesaurus concept]
- antithrombin iii [SNOMED Notion]
- heparin cofactor i [SNOMED Notion]
OMIM relation
- Serpin peptidase inhibitor, clade C (antithrombin), member 1 [OMIM gene]
See also inter- (CISMeF)
- Antithrombin III [MedDRA Preferred Term]
- Product containing antithrombin III (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- SERPINC1 protein, human [MeSH Supplementary Concept]
- SERPINC1 protein, human [MeSH concept]
Validated automatic mappings to BTNT
- SERPINC1 protein, human [MeSH Supplementary Concept]
- SERPINC1 protein, human [MeSH concept]
- antithrombin III [ATC Code]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Inhibitor Gene [NCIt concept]
- Proteinase Inhibitor Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- SERPINC1 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Serpin [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- Complement and Coagulation Cascade [NCIt concept]
- Glypican 1 Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Coagulation Process [NCIt concept]
- Enzyme Inhibition [NCIt concept]
- Regulation of Proteolysis [NCIt concept]
is_target
- Fondaparinux Sodium [NCIt concept]
- Semuloparin [NCIt concept]

Keyword's position in hierarchy(ies) :

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