" /> Semuloparin - CISMeF





Preferred Label : Semuloparin;

NCIt synonyms : Ultralow-Molecular-Weight Heparin AVE5026; ULMW heparin AVE5026; Ultra-low-molecular-weight Heparin (2000-3000 MW; Phosphazene Depolymerization);

NCIt definition : An ultralow-molecular-weight heparin (ULMWH) (Mw: 2000-3000 daltons)consisting of a polydisperse mixture of oligomeric heparin fragments with potential anticoagulant activity. Ultralow-molecular-weight heparin AVE5026 binds to and activates antithrombin III (ATIII), which may result in the inhibition of activated factor Xa and, to a much lesser extent, factor IIa (thrombin) and so the inhibition of fibrin formation. Compared to low-molecular-weight heparins (LMWHs), AVE5026 exhibits an even higher ratio of anti-Factor Xa to anti-Factor IIa activity ( 30:1). Compared to unfractionated heparins, the use of LMWHs is associated with lower incidences of major bleeding, osteoporosis and heparin-induced thrombocytopenia. Like LMWHs, this agent may inhibit tumor growth by regulating angiogenesis and apoptosis. AVE5026 is prepared by partial depolymerization of unfractionated porcine mucosal heparin.;

UNII : 4QW4AN84NQ;

CAS number : 9005-49-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 9005-49-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : AVE-5026;

ChEBI ID : CHEBI:28304;

Codes from synonyms : 463;

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15/05/2024


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