Coagulation Factor VII

Preferred Label : Coagulation Factor VII;

NCIt synonyms : Factor VII; EC 3.4.21.21; Serum Prothrombin Conversion Accelerator; F7; Coagulation Factor-VII; Proconvertin;

NCIt definition : Coagulation factor VII (466 aa, 52 kDa) is encoded by the human F7 gene. This protein is involved in both binding to tissue factor and the initiation of blood coagulation.;

NCIt note : Coagulation factor VII is converted from a zymogen to an active protease through a single proteolytic cleavage by by factor Xa, factor XIIa, factor IXa, or thrombin. (UniProt);

Details

Origin ID

C16570;

UMLS CUI

C5441682;

Automatic exact mappings (from CISMeF team)
- BAY 86-6150 [MeSH Supplementary Concept]
- Coagulation factor VII [OMIM gene]
- Coagulation factor VII level [MedDRA Preferred Term]
- Coagulation factor VII level low [MedDRA LLT]
- Coagulation factor VIII level [MedDRA Preferred Term]
- Coagulation factor VIII level low [MedDRA LLT]
- coagulation factor VII [ORDO Gene]
- coagulation factor VII [HGNC gene]
- factor VIII [MeSH concept]
- factor VIII [MeSH Descriptor]
- factor VIIa [MeSH concept]
- recombinant FVIIa [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- Coagulation factor VII [LOINC component]
- Coagulation factor VII [ICD-11 Extension code]
- Coagulation factor VII (substance) [SNOMED CT concept]
- blood-coagulation factor vii [Substance BNPC]
- coagulation factor VII [ATC Code]
- coagulation factor vii [medical devices type]
- coagulation factor vii [SNOMED Notion]
- factor VII [Blood Transfusion thesaurus concept]
- factor VII [MeSH Descriptor]
- factor VII [MeSH concept]
OMIM relation
- Coagulation factor VII [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Coagulation factor VII [LOINC component]
- Coagulation factor VII (substance) [SNOMED CT concept]
- Product containing coagulation factor VII (medicinal product) [SNOMED CT concept]
- blood-coagulation factor vii [Substance BNPC]
- coagulation factor VII [ATC Code]
- coagulation factor vii [SNOMED Notion]
- factor VII [MeSH concept]
- factor VII [MeSH Descriptor]
Validated automatic mappings to BTNT
- Eptacog alfa (activated) [SMS substance]
- Eptacog alfa (substance) [SNOMED CT concept]
- coagulation factor VIIa [ATC Code]
- eptacog alfa [MeSH concept]
- factor VIIa [MeSH Descriptor]
gene_encodes_gene_product
- Coagulation Factor Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- F7 Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_expressed_in_tissue
- Liver [NCIt concept]
gene_product_has_chemical_classification
- Glycoprotein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Acute Myocardial Infarction Pathway [NCIt concept]
- Complement and Coagulation Cascade [NCIt concept]
- Extrinsic Prothrombin Activation Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Calcium Binding [NCIt concept]
- Coagulation Process [NCIt concept]
- Homeostatic Process [NCIt concept]
- Hydrolysis [NCIt concept]
- Ligand Binding [NCIt concept]
- Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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