Preferred Label : factor VIII;

MeSH definition : Blood-coagulation factor VIII. Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.; Factor VIII of blood coagulation. Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.;

MeSH synonym : coagulation factor viii; blood coagulation factor viii; thromboplastinogen; Factor 8; Factor Eight;

CISMeF synonym : humate p; humatep; factor viii, coagulation; viii, coagulation factor; factor viii heavy chain; factor viii-heavy chain; speywood brand of porcine factor VIII preparation;

DeCS synonym : Factor 8 C;

MeSH hyponym : hyate-c; Hyatt-C; Hyatt C; HyattC; Hyate C; HyateC;

Related MeSH term : factor VIIIC; factor VIII procoagulant activity; factor VIII coagulant antigen; Factor 8 C; F VIII-C; F VIII C; Factor VIII Clotting Antigen;

MeSH CAS label : blood-coagulation factor VIII, complex;

Registry Number MeSH : 9001-27-8;

Wikipedia link : https://en.wikipedia.org/wiki/Factor VIII;

Codes EINECS : 232-593-9;

Is substance : O;

Details


Main resources

You can consult :

Blood-coagulation factor VIII. Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.
Factor VIII of blood coagulation. Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.

https://www.has-sante.fr/jcms/p_3242180/fr/esperoct
2021
false
false
false
France
insurance, health, reimbursement
treatment outcome
Turoctocog Alfa Pegol
Turoctocog Alfa Pegol
factor VIII
factor VIII
recombinant proteins
polyethylene glycols
polyethylene glycols
injections, intravenous
hemorrhage
hemophilia A
coagulation factor VIII
adolescent
adult
evaluation of the transparency committee

---
https://site.geht.org/app/uploads/2019/08/Lasne-et-al-Dosage-de-lactivit%C3%A9-du-facteur-VIII-chez-les-patients-h%C3%A9mophiles-A-substitu%C3%A9s-ABC-2019.pdf
2019
false
false
false
France
Factor VIII Activity Measurement
hemophilia A
continuity of patient care
hemophilia A
blood chemical analysis
monitoring, physiologic
blood coagulation tests
journal article
factor VIII

---
https://www.ema.europa.eu/en/medicines/human/EPAR/esperoct
2019
false
false
false
United Kingdom
French
English
treatment outcome
syndication feed
summary of product characteristics
package leaflet
drug evaluation
Turoctocog Alfa Pegol
Turoctocog Alfa Pegol
drug approval
europe
factor VIII
factor VIII
polyethylene glycols
polyethylene glycols
adult
child
adolescent
aged
hemorrhage
hemorrhage
hemophilia A
injections, intravenous
coagulation factor VIII
product surveillance, postmarketing

---
https://www.has-sante.fr/jcms/p_3067174/fr/jivi
2019
false
false
false
France
French
recombinant proteins
factor VIII
evaluation of the transparency committee
treatment outcome
hemorrhage
hemorrhage
hemophilia A
adolescent
adult
injections, intravenous
polyethylene glycols

---
https://www.has-sante.fr/portail/jcms/c_2965047/fr/adynovi
https://www.has-sante.fr/portail/jcms/c_2965047/fr/adynovi-rurioctocog-alfa-pegol-facteur-anti-hemophilique-facteur-viii
2019
false
false
false
France
French
treatment outcome
hemophilia A
hemorrhage
hemorrhage
adult
adolescent
aged
injections, intravenous
factor VIII
recombinant proteins
coagulation factor VIII
evaluation of the transparency committee
guidelines for drug use

---
https://www.ema.europa.eu/en/medicines/human/EPAR/jivi
2019
false
false
false
United Kingdom
French
English
treatment outcome
syndication feed
summary of product characteristics
package leaflet
drug evaluation
factor VIII
factor VIII
recombinant proteins
polyethylene glycols
polyethylene glycols
drug approval
europe
hemorrhage
hemorrhage
adult
adolescent
child
hemophilia A
injections, intravenous
product surveillance, postmarketing
drug evaluation, preclinical

---
https://www.has-sante.fr/portail/jcms/c_2863574/fr/eqwilate
https://www.has-sante.fr/portail/jcms/c_2863574/fr/eqwilate-facteur-von-willebrand-facteur-viii-de-coagulation-humain
2018
false
false
false
false
France
French
evaluation of the transparency committee
drug combinations
treatment outcome
von willebrand factor
F8 protein, human
hemophilia A
von willebrand diseases
hemorrhage
hemorrhage
blood loss, surgical
blood loss, surgical
guidelines for drug use
von willebrand factor and coagulation factor VIII in combination
factor VIII

---
https://www.ema.europa.eu/medicines/human/EPAR/Adynovi
2018
false
false
false
United Kingdom
French
English
syndication feed
summary of product characteristics
package leaflet
drug evaluation
drug approval
europe
treatment outcome
hemophilia A
hemorrhage
hemorrhage
adult
adolescent
aged
injections, intravenous
factor VIII
recombinant proteins
recombinant proteins
coagulation factor VIII
product surveillance, postmarketing
continuity of patient care
drug evaluation, preclinical

---
https://www.has-sante.fr/portail/jcms/c_2808586/fr/kovaltry-octocog-alfa-facteur-anti-hemophilique-facteur-viii
https://www.has-sante.fr/portail/jcms/c_2808586/fr/kovaltry
2017
false
false
France
French
evaluation of the transparency committee
octocog alfa
octocog alfa
guidelines for drug use
F8 protein, human
F8 protein, human
hemophilia A
hemorrhage
hemorrhage
factor VIII
factor VIII
treatment outcome
injections, intravenous
recombinant proteins
coagulation factor VIII

---
https://www.has-sante.fr/portail/jcms/c_2788650/fr/afstyla
2017
false
false
false
France
French
treatment outcome
factor VIII
factor VIII
hemophilia A
hemorrhage
hemorrhage
coagulation factor VIII
Product containing coagulation factor VIII (medicinal product)
injections, intravenous
adult
child
adolescent
aged
infant
recombinant proteins
recombinant proteins
evaluation of the transparency committee

---
https://www.ema.europa.eu/medicines/human/EPAR/Vihuma
2017
false
false
false
United Kingdom
French
English
treatment outcome
syndication feed
drug evaluation
factor VIII
factor VIII
recombinant proteins
drug approval
europe
coagulation factor VIII
hemophilia A
hemorrhage
hemorrhage
injections, intravenous
summary of product characteristics
package leaflet
pregnancy
breast feeding
drug interactions
Product containing coagulation factor VIII (medicinal product)

---
https://www.ema.europa.eu/medicines/human/EPAR/Afstyla
2017
false
false
false
United Kingdom
French
English
syndication feed
summary of product characteristics
package leaflet
drug evaluation
drug approval
europe
treatment outcome
factor VIII
factor VIII
hemophilia A
hemorrhage
hemorrhage
coagulation factor VIII
Product containing coagulation factor VIII (medicinal product)
pregnancy
breast feeding
drug interactions
injections, intravenous
product surveillance, postmarketing
continuity of patient care
adult
child
adolescent
aged
infant
drug storage

---
http://circulaire.legifrance.gouv.fr/index.php?action=afficherCirculaire&hit=1&r=41904
2017
false
false
false
France
French
legislation
factor VIIa
relative
education, nos
hemophilia, nos
mars
factor IX
anti-factor viii
Health Care Category
factor VIII
anti-factor ix

---
https://www.has-sante.fr/portail/jcms/c_2733618/fr/kovaltry
2016
false
France
French
evaluation of the transparency committee
octocog alfa
octocog alfa
F8 protein, human
F8 protein, human
hemophilia A
hemorrhage
hemorrhage
factor VIII
factor VIII
treatment outcome
injections, intravenous
recombinant proteins
coagulation factor VIII

---
https://www.has-sante.fr/portail/jcms/c_2733600/fr/iblias
2016
false
France
French
octocog alfa
octocog alfa
evaluation of the transparency committee
F8 protein, human
F8 protein, human
hemophilia A
hemorrhage
hemorrhage
factor VIII
factor VIII
treatment outcome
injections, intravenous
recombinant proteins
coagulation factor VIII

---
https://www.has-sante.fr/portail/jcms/c_2732125/fr/obizur-susoctogog-alfa-facteur-viii-recombinant-de-sequence-porcine
https://www.has-sante.fr/portail/jcms/c_2732125/fr/obizur
2016
false
false
false
France
French
evaluation of the transparency committee
guidelines for drug use
treatment outcome
susoctocog alfa
hemorrhage
factor VIII
recombinant proteins
injections, intravenous
factor 8 deficiency, acquired
factor VIII
continuity of patient care
hemophilia A

---
ADYNOVATE - Summary Basis of Decision (SBD)
Antihemophilic Factor VIII (Recombinant), PEGylated
https://hpr-rps.hres.ca/reg-content/sommaire-motif-decision-detailTwo.php?lang=fr&linkID=SBD00340
2016
false
false
false
Canada
French
English
drug evaluation
factor VIII
factor VIII
recombinant proteins
recombinant proteins
drug approval
canada
hemorrhage
hemorrhage
intraoperative care
hemophilia A
polyethylene glycols
treatment outcome
summary of product characteristics
coagulation factor VIII
injections, intravenous
BAX 855
BAX 855

---
http://www.has-sante.fr/portail/jcms/c_2642074/fr/voncento
http://www.has-sante.fr/portail/jcms/c_2642074/fr/voncento-facteur-viii-de-coagulation-humain-facteur-von-willebrand
2016
false
false
false
false
France
French
evaluation of the transparency committee
treatment outcome
drug combinations
von willebrand factor
factor VIII
hemorrhage
hemorrhage
von willebrand diseases
postoperative hemorrhage
postoperative hemorrhage
blood loss, surgical
blood loss, surgical
hemophilia A
injections, intravenous
infusions, intravenous
von willebrand factor and coagulation factor VIII in combination
child
guidelines for drug use

---
https://www.ema.europa.eu/medicines/human/EPAR/Kovaltry
2016
false
United Kingdom
English
French
syndication feed
F8 protein, human
F8 protein, human
hemophilia A
hemorrhage
hemorrhage
factor VIII
factor VIII
treatment outcome
drug evaluation
drug approval
drug labeling
injections, intravenous
recombinant proteins
drug storage
drug compounding
coagulation factor VIII
factor VIII
drug evaluation
summary of product characteristics
package leaflet

---
https://www.ema.europa.eu/medicines/human/EPAR/Iblias
2016
false
United Kingdom
English
French
syndication feed
octocog alfa
octocog alfa
F8 protein, human
F8 protein, human
hemophilia A
hemorrhage
hemorrhage
factor VIII
factor VIII
treatment outcome
drug evaluation
drug approval
drug labeling
injections, intravenous
recombinant proteins
drug storage
drug compounding
coagulation factor VIII
factor VIII
drug evaluation
summary of product characteristics
package leaflet

---
http://www.has-sante.fr/portail/jcms/c_2617853/fr/elocta
http://www.has-sante.fr/portail/jcms/c_2617853/fr/elocta-efmoroctocog-alfa-facteur-viii
2016
false
false
false
France
French
treatment outcome
factor VIII-Fc fusion protein
factor VIII-Fc fusion protein
coagulation factor VIII
hemophilia A
hemorrhage
hemorrhage
orphan drug production
injections, intravenous
evaluation of the transparency committee
adult
adolescent
child
guidelines for drug use
factor VIII
immunoglobulin fc fragments
recombinant fusion proteins
factor VIII
immunoglobulin fc fragments
recombinant fusion proteins

---
http://www.has-sante.fr/portail/jcms/c_2611689/fr/kogenate-bayer
2016
false
France
French
evaluation of the transparency committee
F8 protein, human
hemorrhage
hemophilia A
hemorrhage
factor VIII
treatment outcome
injections, intravenous
coagulation factor VIII

---
http://www.has-sante.fr/portail/jcms/c_2583332/fr/octanate-lv
2015
false
false
false
false
France
French
evaluation of the transparency committee
factor VIII
factor VIII
F8 protein, human
F8 protein, human
hemophilia A
hemorrhage
hemorrhage
coagulation factor VIII
injections, intravenous

---
https://www.ema.europa.eu/medicines/human/EPAR/Elocta
2015
false
false
false
United Kingdom
French
English
treatment outcome
syndication feed
summary of product characteristics
package leaflet
drug evaluation
drug approval
europe
factor VIII-Fc fusion protein
factor VIII-Fc fusion protein
hemophilia A
hemorrhage
hemorrhage
orphan drug production
product surveillance, postmarketing
injections, intravenous
pregnancy
breast feeding
drug evaluation, preclinical
coagulation factor VIII
factor VIII
immunoglobulin fc fragments
recombinant fusion proteins
factor VIII
immunoglobulin fc fragments
recombinant fusion proteins

---
https://www.ema.europa.eu/medicines/human/EPAR/Nuwiq
2015
false
false
false
United Kingdom
French
English
treatment outcome
syndication feed
drug evaluation
factor VIII
factor VIII
recombinant proteins
drug approval
europe
coagulation factor VIII
hemophilia A
hemorrhage
hemorrhage
injections, intravenous

---
https://www.ema.europa.eu/medicines/human/EPAR/Obizur
2015
false
false
false
United Kingdom
French
English
treatment outcome
syndication feed
summary of product characteristics
package leaflet
drug evaluation
drug approval
europe
factor VIII
factor VIII
recombinant proteins
recombinant proteins
hemophilia A
product surveillance, postmarketing
pregnancy
breast feeding
drug interactions
drug evaluation, preclinical
adult
hemorrhage
injections, intravenous
susoctocog alfa
factor 8 deficiency, acquired

---
Summary Basis of Decision (SBD) for Obizur
Antihemophilic Factor (Recombinant), Porcine Sequence 500 Units/mL, powder for solution, intravenous
https://hpr-rps.hres.ca/reg-content/sommaire-motif-decision-detailTwo.php?lang=fr&linkID=SBD00240
2015
false
false
false
Canada
French
English
treatment outcome
summary of product characteristics
drug approval
canada
antihemorrhagics
factor VIII
factor VIII
recombinant proteins
recombinant proteins
hemophilia A
drug evaluation, preclinical
adult
hemorrhage
injections, intravenous
aged
drug evaluation
factor 8 deficiency, acquired
risk management

---
Summary Basis of Decision (SBD) for NUWIQ
Simoctocog alfa, 250 IU/vial, 500 IU/vial, 1000 IU/vial, 2000 IU/vial, Powder for solution, intravenous injection
https://hpr-rps.hres.ca/reg-content/summary-basis-decision-detailTwo.php?lang=en&linkID=SBD00235
2015
false
false
false
Canada
French
English
treatment outcome
factor VIII
factor VIII
recombinant proteins
drug approval
canada
coagulation factor VIII
hemophilia A
hemorrhage
hemorrhage
injections, intravenous
summary of product characteristics
adult

---
http://www.has-sante.fr/portail/jcms/c_2050483/fr/nuwiq-simoctocog-alfa-facteur-anti-hemophilique-facteur-viii
http://www.has-sante.fr/portail/jcms/c_2050483/fr/nuwiq
2015
false
false
false
France
French
evaluation of the transparency committee
guidelines for drug use
factor VIII
recombinant proteins
hemorrhage
hemorrhage
injections, intravenous
hemophilia A
treatment outcome
HEK293 cells
factor VIII
coagulation factor VIII

---
http://www.has-sante.fr/portail/jcms/c_2049892/fr/kogenate-bayer
http://www.has-sante.fr/portail/jcms/c_2049892/fr/kogenate-bayer-octocog-alfa-facteur-viii-de-coagulation-humaine-recombinant
2015
false
France
French
evaluation of the transparency committee
guidelines for drug use
F8 protein, human
hemorrhage
hemophilia A
hemorrhage
factor VIII
factor VIII
treatment outcome
injections, intravenous
coagulation factor VIII
factor VIII

---
http://www.has-sante.fr/portail/jcms/c_2049886/fr/helixate-nexgen
http://www.has-sante.fr/portail/jcms/c_2049886/fr/helixate-nexgen-octocog-alfa-facteur-viii-de-coagulation-humaine-recombinant
2015
true
France
French
evaluation of the transparency committee
guidelines for drug use
F8 protein, human
F8 protein, human
hemophilia A
hemorrhage
hemorrhage
factor VIII
factor VIII
treatment outcome
injections, intravenous
recombinant proteins
coagulation factor VIII

---
http://www.has-sante.fr/portail/jcms/c_1747223/fr/voncento-facteur-viii-de-coagulation-humain-facteur-von-willebrand-facteurs-de-coagulation
2014
false
false
false
France
French
guidelines for drug use
evaluation of the transparency committee
treatment outcome
drug combinations
von willebrand factor
factor VIII
hemorrhage
hemorrhage
von willebrand diseases
postoperative hemorrhage
postoperative hemorrhage
blood loss, surgical
blood loss, surgical
hemophilia A
injections, intravenous
infusions, intravenous
von willebrand factor and coagulation factor VIII in combination

---
Summary Basis of Decision (SBD) for Eloctate
Antihemophilic Factor (Recombinant BDD), Fc Fusion Protein, 250, 500, 750, 1,000, 1,500, 2,000, 3,000 IU/vial, powder for solution, intravenous
https://hpr-rps.hres.ca/reg-content/sommaire-motif-decision-detailTwo.php?lang=fr&linkID=SBD00210
2014
false
false
false
Canada
French
English
drug information
adult
child
hemophilia A
hemorrhage
factor VIII
factor VIII
coagulation factor VIII
coagulants
coagulants
immunoglobulin fc fragments
immunoglobulin fc fragments
recombinant fusion proteins
recombinant fusion proteins
drug approval
canada
treatment outcome
chemoprevention
hemorrhage

---
https://www.ema.europa.eu/medicines/human/EPAR/Voncento
2013
false
United Kingdom
French
English
factor VIII
F8 protein, human
von willebrand factor
drug combinations
von willebrand factor
F8 protein, human
factor VIII
drug approval
treatment outcome
europe
hemophilia A
blood loss, surgical
hemorrhage
hemorrhage
von willebrand diseases
postoperative hemorrhage
postoperative hemorrhage
injections, intravenous
infusions, intravenous
von willebrand factor and coagulation factor VIII in combination
product surveillance, postmarketing
pregnancy
summary of product characteristics
package leaflet
drug evaluation
syndication feed

---
http://www.has-sante.fr/portail/jcms/c_1670195/fr/factane
http://www.has-sante.fr/portail/jcms/c_1670627/fr/factane-16102013-avis-ct13137
2013
false
France
French
evaluation of the transparency committee
factor VIII
F8 protein, human
coagulation factor VIII
hemophilia A
hemorrhage
hemorrhage
injections, intravenous

---
https://www.ema.europa.eu/medicines/human/EPAR/Kogenate-Bayer
2012
United Kingdom
French
English
syndication feed
Contraindications, Procedure
F8 protein, human
hemorrhage
hemophilia A
hemorrhage
factor VIII
factor VIII
factor VIII
factor VIII
treatment outcome
drug evaluation
injections, intravenous
coagulation factor VIII
drug evaluation
summary of product characteristics
package leaflet
Contraindications, Drug

---
https://www.ema.europa.eu/medicines/human/EPAR/refacto-af
2012
false
United Kingdom
English
French
syndication feed
factor VIII
hemophilia A
hemorrhage
treatment outcome
drug evaluation
recombinant factor VIII SQ
factor VIII
recombinant factor VIII SQ
coagulation factor VIII
drug evaluation
summary of product characteristics
package leaflet

---
https://www.ema.europa.eu/medicines/human/EPAR/Helixate-NexGen
2012
false
United Kingdom
English
French
syndication feed
F8 protein, human
F8 protein, human
hemophilia A
hemorrhage
hemorrhage
factor VIII
factor VIII
treatment outcome
drug evaluation
drug approval
drug labeling
injections, intravenous
recombinant proteins
drug storage
drug compounding
coagulation factor VIII
factor VIII
drug evaluation
summary of product characteristics
package leaflet

---
https://www.ema.europa.eu/medicines/human/EPAR/Advate
2012
United Kingdom
French
English
syndication feed
F8 protein, human
F8 protein, human
hemophilia A
hemorrhage
hemorrhage
factor VIII
factor VIII
treatment outcome
drug evaluation
drug approval
drug labeling
infusions, intravenous
pregnancy
breast feeding
drug storage
drug compounding
coagulation factor VIII
factor VIII
drug evaluation
summary of product characteristics
package leaflet

---
http://www.has-sante.fr/portail/jcms/c_1009982/biologie-des-anomalies-de-lhemostase-rapport-d-evaluation
http://www.has-sante.fr/portail/jcms/c_1084558/biologie-anomalie-hemostase-t1-temps-de-saignement-rapport-d-evaluation
http://www.has-sante.fr/portail/jcms/c_1084559/biologie-anomalie-hemostase-t2-thrombine-rapport-d-evaluation
http://www.has-sante.fr/portail/jcms/c_1084560/biologie-anomalie-hemostase-t3-tap-rapport-d-evaluation
http://www.has-sante.fr/portail/jcms/c_1084561/biologie-anomalie-hemostase-t4-ac-anti-f4p-rapport-d-evaluation
http://www.has-sante.fr/portail/jcms/c_1084562/biologie-anomalie-hemostase-t5-inhibiteurs-fah-rapport-d-evaluation
http://www.has-sante.fr/portail/jcms/c_1084563/biologie-anomalie-hemostase-t6-al-rapport-d-evaluation
http://www.has-sante.fr/portail/jcms/c_1084564/biologie-anomalie-hemostase-t7-mutations-fii-et-fv-rapport-d-evaluation
2011
true
France
French
health technology assessment
hemostatic disorders
bleeding time
thrombin time
platelet aggregation
platelet factor 4
factor VIII
lupus coagulation inhibitor
factor v
prothrombin
factor V leiden

---
http://www.has-sante.fr/portail/upload/docs/application/pdf/ct032423.pdf
http://www.has-sante.fr/portail/display.jsp?id=c_400845
2006
France
French
coagulation factor VIII
F8 protein, human
factor VIII
infusions, intravenous
child
recombinant proteins
hemorrhage
hemorrhage
hemophilia A
treatment outcome
F8 protein, human
factor VIII
factor VIII
evaluation of the transparency committee

---
http://www.has-sante.fr/portail/display.jsp?id=c_245565
2005
France
French
hemorrhage
hemorrhagic disorders
factor VIII
recombinant proteins
coagulation factor VIII
factor VIII
F8 protein, human
evaluation of the transparency committee

---
http://www.has-sante.fr/portail/display.jsp?id=c_245127
2004
France
French
factor VIII
F8 protein, human
coagulation factor VIII
guidelines for drug use

---
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