platelet factor 4

Preferred Label : platelet factor 4;

MeSH definition : A CXC chemokine that is found in the alpha granules of PLATELETS. The protein has a molecular size of 7800 kDa and can occur as a monomer, a dimer or a tetramer depending upon its concentration in solution. Platelet factor 4 has a high affinity for HEPARIN and is often found complexed with GLYCOPROTEINS such as PROTEIN C.;

MeSH synonym : cxcl4, chemokine; pf4 (platelet factor 4); heparin neutralizing protein; cxcl4 chemokine; chemokine, cxcl4; chemokine cxcl4; gamma-thromboglobulin; gamma thromboglobulin; antiheparin factor;

MeSH CAS label : blood platelet factor 4;

Registry Number MeSH : 37270-94-3;

Wikipedia link : https://en.wikipedia.org/wiki/Platelet factor 4;

Is substance : O;

Details

Origin ID

D010978;

UMLS CUI

C0032183;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Iroplact [NCIt concept]
- Platelet Factor 4 [NCIt concept]
- Platelet factor 4 [LOINC component]
- Platelet factor 4 [MedDRA Preferred Term]
- Platelet factor 4 (substance) [SNOMED CT concept]
- platelet factor 4 [SNOMED Notion]
Indexing information
- C18G peptide [MeSH Supplementary Concept]
Pharmacological action(s)
- coagulants [MeSH Descriptor]
Record concept(s)
- platelet factor 4 [MeSH concept]
Related MeSH Supplementary Concept(s)
- PF4 protein, human [MeSH Supplementary Concept]
- PF4V1 protein, human [MeSH Supplementary Concept]
- platelet factor 4 (47-70) [MeSH Supplementary Concept]
- platelet factor 4 (59-70) [MeSH Supplementary Concept]
- recombinant PF4-241 [MeSH Supplementary Concept]
See also (suggested by CISMeF)
- heparin antagonists [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- Platelet factor 4 [LOINC component]
- Platelet factor 4 (substance) [SNOMED CT concept]
- platelet factor 4 [SNOMED Notion]

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