prothrombin - CISMeF

Preferred Label : prothrombin;

MeSH definition : A plasma protein that is the inactive precursor of thrombin. It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. Deficiency of prothrombin leads to hypoprothrombinemia.;

MeSH synonym : factor, differentiation reversal; factor ii; factor ii, coagulation; ii, coagulation factor; blood coagulation factor ii; differentiation reversal factor; coagulation factor ii;

Wikipedia automatic translation : Thrombin;

MeSH CAS label : blood-coagulation factor II;

Registry Number MeSH : 9001-26-7;

MeSH annotation : a blood coag factor; an enzyme precursor;

Wikipedia link : https://en.wikipedia.org/wiki/Thrombin;

Codes EINECS : 232-592-3;

Is substance : O;

Details

Origin ID

D011516;

UMLS CUI

C0033706;

ATC code(s)
- coagulation factor ix, ii, vii and x in combination [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Coagulation Factor [NCIt concept]
- Coagulation factor [MedDRA Preferred Term]
- Coagulation factor II [OMIM gene]
- Complement factor b [OMIM Phenotype]
- Factor [NCIt concept]
- Mathematical Factor [NCIt concept]
- Prothrombin [LOINC component]
- Prothrombin antibody (substance) [SNOMED CT concept]
- blood coagulation factors [ATC Code]
- blood-coagulation factor iii [Substance BNPC]
- blood-coagulation factor v [Substance BNPC]
- blood-coagulation factor x [Substance BNPC]
- coagulation factor i [SNOMED Notion]
- coagulation factor iii [SNOMED Notion]
- coagulation factor v [SNOMED Notion]
- coagulation factor x [SNOMED Notion]
- coagulation factor, nos [SNOMED Notion]
- f factor [SNOMED Notion]
- factor [IUPAC Term]
- factor h [SNOMED Notion]
- fibrinogens [Substance BNPC]
- prothrombin [Blood Transfusion thesaurus concept]
- r factor [SNOMED Notion]
CISMeF manual mappings
- blood-coagulation factor ii [Substance BNPC]
Currated CISMeF NLP mapping
- Coagulation factor II (substance) [SNOMED CT concept]
- Coagulation factor II level [MedDRA LLT]
- Prothrombin [MedDRA LLT]
- Prothrombin Measurement [NCIt concept]
- Prothrombin level [MedDRA Preferred Term]
- coagulation factor ii [SNOMED Notion]
Indexing information
- anti-prothrombin autoantibody [MeSH Supplementary Concept]
- insularinase A, bothrops insularis [MeSH Supplementary Concept]
- preprothrombin carboxylase [MeSH Supplementary Concept]
- prothrombin activator protein, bothrops atrox venom [MeSH Supplementary Concept]
Record concept(s)
- prothrombin [MeSH concept]
Related MeSH Supplementary Concept(s)
- Profilnine SD [MeSH Supplementary Concept]
- acarboxyprothrombin [MeSH Supplementary Concept]
- acetylcysteinyl-leucyl-glutamyl-glutamyl-prolyl-cysteine methyl ester cyclic disulfide [MeSH Supplementary Concept]
- chemotactic peptide CB67-129 [MeSH Supplementary Concept]
- cysteinyl-leucyl-glutamyl-glutamyl-prolyl-cysteine cyclic disulfide [MeSH Supplementary Concept]
- factor II clotting antigen [MeSH Supplementary Concept]
- factor IIa [MeSH Supplementary Concept]
- factor IX, factor VII, factor X, prothrombin drug combination [MeSH Supplementary Concept]
- preconativ [MeSH Supplementary Concept]
- prethrombins [MeSH Supplementary Concept]
- prothrombin (1-45) [MeSH Supplementary Concept]
- prothrombin (1-46), Trp(4)- [MeSH Supplementary Concept]
- prothrombin (18-23) [MeSH Supplementary Concept]
- prothrombin (35-62) [MeSH Supplementary Concept]
- prothrombin (des 1-44) [MeSH Supplementary Concept]
- prothrombin activator (Taipan venom) [MeSH Supplementary Concept]
- prothrombin barcelona [MeSH Supplementary Concept]
- prothrombin clamart [MeSH Supplementary Concept]
- prothrombin fragment 1 [MeSH Supplementary Concept]
- prothrombin fragment 1.2 [MeSH Supplementary Concept]
- prothrombin fragment 1.2.3 [MeSH Supplementary Concept]
- prothrombin fragment 2 [MeSH Supplementary Concept]
- prothrombin frankfurt [MeSH Supplementary Concept]
- prothrombin greenville [MeSH Supplementary Concept]
- prothrombin habana [MeSH Supplementary Concept]
- prothrombin himi [MeSH Supplementary Concept]
- prothrombin magdeburg [MeSH Supplementary Concept]
- prothrombin metz [MeSH Supplementary Concept]
- prothrombin perija [MeSH Supplementary Concept]
- prothrombin poissy [MeSH Supplementary Concept]
- prothrombin precursor (13-29) [MeSH Supplementary Concept]
- prothrombin residue (1-39) [MeSH Supplementary Concept]
- prothrombin salakta [MeSH Supplementary Concept]
- prothrombin san antonio [MeSH Supplementary Concept]
- prothrombin scranton [MeSH Supplementary Concept]
- prothrombin tokushima [MeSH Supplementary Concept]
- prothrombin type 3 [MeSH Supplementary Concept]
- prothrombin, Gla(9)- [MeSH Supplementary Concept]
- trocarin [MeSH Supplementary Concept]
Related MeSH term(s)
- hypoprothrombinemias [MeSH Descriptor]
See also
- coagulants [MeSH Descriptor]
See also (suggested by CISMeF)
- prothrombin time [MeSH Descriptor]
See also inter- (CISMeF)
- Prothrombin [NCIt concept]
- Prothrombin [NCIt concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Coagulation factor II (substance) [SNOMED CT concept]
- Prothrombin [LOINC component]
- coagulation factor ii [SNOMED Notion]

Keyword's position in hierarchy(ies) :

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