Preferred Label : Dabigatran;

MeSH definition : A THROMBIN inhibitor which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation. It is used to reduce the risk of stroke and systemic EMBOLISM in patients with nonvalvular atrial fibrillation.;

MeSH synonym : N-((2-(((4-(aminoiminomethyl)phenyl)amino)methyl)-1-methyl-1H-benzimidazol-5-yl)carbonyl)-N-2-pyridinyl-beta-alanine;

MeSH hyponym : BIBR 1048; dabigatran etexilate; Pradaxa; dabigatran etexilate mesylate; Etexilate, Dabigatran; Etexilate Mesylate, Dabigatran; Mesylate, Dabigatran Etexilate;

MeSH Related Number : 2E18WX195X; SC7NUW5IIT;

Wikipedia link : https://en.wikipedia.org/wiki/Dabigatran;

Is substance : O;

UNII : I0VM4M70GC;

Details


Main resources

You can consult :

A THROMBIN inhibitor which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation. It is used to reduce the risk of stroke and systemic EMBOLISM in patients with nonvalvular atrial fibrillation.

https://ansm.sante.fr/tableau-marr/dabigatran
2024
false
false
false
France
French
guidelines for drug use
risk management
Dabigatran
Dabigatran
dabigatran etexilate
administration, oral
antithrombins
antithrombins
continuity of patient care
hemorrhage
risk
adult
child

---
https://www.has-sante.fr/jcms/p_3478094/fr/pradaxa-dabigatran-etexilate-traitement-des-evenements-thromboemboliques-veineux-etev-pediatrique
2024
false
false
false
France
child
adolescent
evaluation of the transparency committee
pediatrics
During Treatment
Biomaterial Treatment
Treatment
Venous Thromboembolism
Dabigatran Etexilate Mesylate
Treatment Study
pediatrician
On Treatment
venous thromboembolism
GDC Treatment Frequency Terminology
Treatment Epoch
Pediatric
vein, nos
Childhood-Onset Systemic Lupus Erythematosus
Thromboembolic Event, CTCAE
Pradaxa
Pediatric
Pediatricians
Therapy Object
Dabigatran Etexilate
dabigatran etexilate
thromboembolus
No Treatment for Diabetes
Dabigatran
thromboembolism
Treat

---
https://www.has-sante.fr/jcms/p_3199398/fr/pradaxa
2020
false
false
false
France
French
evaluation of the transparency committee
guidelines for drug use
treatment outcome
insurance, health, reimbursement
adult
embolism
stroke
atrial fibrillation
venous thromboembolism
postoperative venous thromboembolism
arthroplasty, replacement, knee
arthroplasty, replacement, hip
Dabigatran
administration, oral
antithrombins

---
https://ansm.sante.fr/informations-de-securite/Anticoagulants-Oraux-Directs-AODs-apixaban-Eliquis-R-rivaroxaban-Xarelto-R-dabigatran-Pradaxa-R-et-edoxaban-Lixiana-R-Roteas-R-non-recommandes-chez-les-patients-presentant-un-Syndrome-des-Antiphospholipides-SAPL
2019
false
false
false
France
French
pharmacovigilance note
guidelines for drug use
administration, oral
apixaban
Rivaroxaban
edoxaban
anticoagulants
Dabigatran
recurrence
risk
antiphospholipid syndrome
thrombosis
thrombosis
pyrazoles
pyridones
pyridines
thiazoles

---
https://www.has-sante.fr/portail/jcms/c_2826822/fr/pradaxa
2018
false
false
false
false
France
French
evaluation of the transparency committee
dabigatran etexilate mesylate
Pradaxa
Dabigatran
Dabigatran

---
https://www.has-sante.fr/portail/jcms/c_2851086/fr/les-anticoagulants-oraux
2018
false
false
false
France
French
guidelines for drug use
anticoagulants
anticoagulants
administration, oral
antivitamins K
antivitamins K
atrial fibrillation
drug overdose
apixaban
Dabigatran
antithrombins
Factor Xa Inhibitors
Rivaroxaban
edoxaban
Direct factor Xa inhibitors
direct thrombin inhibitors
pregnancy
patient compliance
continuity of patient care
hemorrhage
surgical procedures, operative
blood loss, surgical
hemorrhage
vitamin k antagonists
fluindione
acenocoumarol
warfarin
pyridines
thiazoles
phenindione
phenindione
indenes
4-hydroxycoumarins
vitamin K
vitamin K
indenes
4-hydroxycoumarins
vitamin K
pyrazoles
pyridones

---
https://www.usherbrooke.ca/baladocritique/archives/episode-18-etude-manage/
2018
false
false
false
false
Canada
French
sound
Dabigatran
operative procedure, nos
wounds and injuries
myocardium
myocardium, nos
injuries
Dabigatran
episode of
data collection
Surgery
Management
surgery, cardiac
patients
heart surgery
has patient
Epidermolytic acanthoma
lesion, nos
Surgery of the heart
heart, nos
general surgery
thoracic surgery

---
https://www.has-sante.fr/portail/jcms/c_2867487/fr/pradaxa
2018
false
false
false
false
France
French
evaluation of the transparency committee
Pradaxa
Dabigatran

---
http://www.pharmactuel.com/index.php/pharmactuel/article/view/1149
2017
false
false
false
Canada
French
journal article
idarucizumab
treatment outcome
idarucizumab
antidotes
antidotes
Anticoagulant reversal therapy
hemorrhage
dabigatran etexilate
antibodies, monoclonal, humanized
antithrombins
reversal of oral anticoagulants
Dabigatran
idarucizumab
anticoagulants
antibodies, monoclonal, humanized
Dabigatran

---
http://kce.fgov.be/fr/publication/report/anticoagulation-et-fibrillation-auriculaire
2017
false
false
false
Belgium
French
anticoagulants
anticoagulants
atrial fibrillation
treatment outcome
stroke
continuity of patient care
Cost-Benefit analysis
medication adherence
risk assessment
hemorrhage
vitamin K
antivitamins K
Rivaroxaban
edoxaban
Dabigatran
apixaban
Factor Xa Inhibitors
antithrombins
belgium
technical report
drug information
comparative study
anticoagulants
economic evaluation
drug monitoring
new oral anticoagulant
indenes
4-hydroxycoumarins
pyridines
thiazoles
pyrazoles
pyridones

---
http://www.centreantipoisons.be/professionnels-de-la-sant/articles-pour-professionnels-de-la-sant/nouveaux-anticoagulants-par-voie
2016
false
false
false
Belgium
French
Dutch
practice guideline
administration, oral
Rivaroxaban
rivaroxaban
anticoagulants
apixaban
Factor Xa Inhibitors
hemorrhage
hemorrhage
hemorrhage
apixaban
dabigatran etexilate
Dabigatran
antithrombins
hospitalization
ambulatory care
pyrazoles
pyridones

---
http://www.has-sante.fr/portail/jcms/c_2735608/fr/pradaxa
http://www.has-sante.fr/portail/jcms/c_2008301/fr/pradaxa
2016
true
France
French
postoperative venous thromboembolism
postoperative complications
venous thromboembolism
arthroplasty, replacement, hip
arthroplasty, replacement, knee
Dabigatran
Dabigatran
thrombin
aged
treatment outcome
insurance, health, reimbursement
administration, oral
stroke
dabigatran etexilate
embolism
antithrombins
atrial fibrillation
risk factors
adult
dabigatran etexilate mesylate
dabigatran etexilate mesylate
evaluation of the transparency committee

---
https://www.revmed.ch/RMS/2016/RMS-N-542/Anticoagulants-oraux-directs-ACOD-une-aide-a-la-prescription-dans-la-pratique-quotidienne
2016
false
false
false
Switzerland
French
journal article
venous thromboembolism
antithrombins
administration, oral
atrial fibrillation
Evidence-Based medicine
guidelines for drug use
recurrence
venous thromboembolism
antithrombins
Direct factor Xa inhibitors
Factor Xa Inhibitors
Factor IIa
dabigatran etexilate
Dabigatran
Rivaroxaban
apixaban
edoxaban
drug interactions
continuity of patient care
clinical chemistry tests
kidney function tests
hemorrhage
surgical procedures, operative
heparin
antivitamins K
patient safety
factor IIa
prothrombin
pyrazoles
pyridones
pyridines
thiazoles
indenes
4-hydroxycoumarins
vitamin K
vitamin K

---
https://www.revmed.ch/RMS/2016/RMS-N-529/Anticoagulants-oraux-directs-quelques-considerations-pratiques
2016
false
false
false
Switzerland
French
journal article
administration, oral
anticoagulants
thromboembolism
thromboembolism
Direct factor Xa inhibitors
direct thrombin inhibitors
aged
neoplasms
liver cirrhosis
obesity
continuity of patient care
drug interactions
antidotes
stroke
treatment outcome
anticoagulants
Dabigatran
Rivaroxaban
apixaban
edoxaban
anticoagulants
Contraindications, Procedure
pyrazoles
pyridones
pyridines
thiazoles
Contraindications, Drug

---
https://www.ema.europa.eu/medicines/human/EPAR/Praxbind
2015
false
false
false
United Kingdom
French
English
summary of product characteristics
package leaflet
idarucizumab
idarucizumab
Anticoagulant reversal therapy
anticoagulants
emergency treatment
hemorrhage
surgical procedures, operative
hemorrhage
hemorrhage
adult
drug evaluation
syndication feed
drug approval
treatment outcome
europe
drug interactions
pregnancy
breast feeding
drug evaluation, preclinical
product surveillance, postmarketing
injections, intravenous
infusions, intravenous
idarucizumab
Dabigatran
reversal of oral anticoagulants
antibodies, monoclonal, humanized
antibodies, monoclonal, humanized
pyridines

---
https://minerva-ebp.be/fr/analyses-en-ligne/277
2015
false
true
false
false
minerva-ebm.be
Belgium
French
comparative study
critical appraisal or critical reading
Dabigatran
anticoagulants
antithrombins
venous thromboembolism
warfarin

---
http://www.ameli.fr/l-assurance-maladie/statistiques-et-publications/etudes-en-sante-publique/etudes-pharmaco-epidemiologiques/nouveaux-anticoagulants-naco-et-risques-associes.php
2015
false
false
false
France
French
technical report
antivitamins K
hemorrhage
stroke
atrial fibrillation
antithrombins
anticoagulants
anticoagulotherapy
Dabigatran
Rivaroxaban

---
http://www.has-sante.fr/portail/jcms/c_2572151/fr/pradaxa
2015
false
France
French
venous thrombosis
venous thrombosis
deep vein thrombosis
deep vein thrombosis
pulmonary embolism
pulmonary embolism
recurrence
Dabigatran
Dabigatran
thrombin
treatment outcome
antithrombins
insurance, health, reimbursement
administration, oral
dabigatran etexilate
antithrombins
adult
dabigatran etexilate mesylate
dabigatran etexilate mesylate
evaluation of the transparency committee

---
https://www.inspq.qc.ca/toxicologie-clinique/idarucizumab-antidote-specifique-du-dabigatran
2015
false
true
false
Canada
French
journal article
Dabigatran
idarucizumab
antibodies, monoclonal, humanized

---
https://www.revmed.ch/RMS/2014/RMS-N-416/Nouveaux-anticoagulants-oraux-donnees-pharmacologiques-a-connaitre-pour-la-pratique-clinique
2014
false
false
false
Switzerland
French
journal article
anticoagulants
administration, oral
antithrombins
factor xa
apixaban
thromboembolism
thromboembolism
drug interactions
renal insufficiency
hepatic insufficiency
aged
obesity
anticoagulants
antithrombins
Factor Xa Inhibitors
anticoagulotherapy
Rivaroxaban
Dabigatran
pyrazoles
pyridones

---
https://www.revmed.ch/RMS/2014/RMS-N-416/Pourquoi-quand-et-comment-doser-les-nouveaux-anticoagulants-oraux
2014
false
false
false
Switzerland
French
journal article
thromboembolism
continuity of patient care
drug monitoring
anticoagulants
administration, oral
rivaroxaban
apixaban
dabigatran etexilate
apixaban
risk factors
blood coagulation tests
kidney failure, chronic
factor xa
antithrombins
Factor Xa Inhibitors
Rivaroxaban
Dabigatran
pyrazoles
pyridones

---
http://www.cfp.ca/content/60/11/e512.full
2014
false
false
false
Canada
French
journal article
anticoagulants
case reports
drug interactions
stroke
atrial fibrillation
venous thromboembolism
apixaban
food-drug interactions
preoperative care
anticoagulotherapy
Dabigatran
Rivaroxaban
pyrazoles
pyridones

---
http://www.cfp.ca/content/60/11/e504.full
2014
false
false
false
Canada
French
anticoagulants
journal article
antithrombins
apixaban
stroke
atrial fibrillation
venous thromboembolism
comparative study
treatment outcome
case reports
warfarin
anticoagulants
anticoagulotherapy
Rivaroxaban
Dabigatran
pyrazoles
pyridones

---
http://www.academie-medecine.fr/rapport-sur-les-anticoagulants-oraux-directs-aod-anterieurement-appeles-nouveaux-anticoagulants-oraux-ou-naco/
http://www.academie-medecine.fr/wp-content/uploads/2014/06/aod2805.pdf
2014
false
false
false
false
France
French
anticoagulants
administration, oral
technical report
anticoagulants
drug interactions
thromboembolism
anticoagulants
pyridines
apixaban
pyrazoles
pyridones
atrial fibrillation
antithrombins
thiazoles
edoxaban
acute coronary syndrome
anticoagulants
vitamin K
orthopedic procedures
anticoagulotherapy
Dabigatran
Dabigatran
Rivaroxaban

---
https://www.jle.com/fr/revues/medecine/met/e-docs/00/04/99/39/resume.phtml
2014
false
France
French
atrial fibrillation
anticoagulants
journal article
thrombosis
vitamin K
drug interactions
practice guideline
aged
risk assessment
apixaban
edoxaban
pyridines
thiazoles
pyrazoles
pyridones
antithrombins
anticoagulotherapy
Rivaroxaban
Dabigatran
antivitamins K
indenes
4-hydroxycoumarins

---
http://www.sciencedirect.com/science/article/pii/S0755498214002590
2014
false
false
false
France
French
atrial fibrillation
anticoagulants
administration, oral
anticoagulants
drug interactions
journal article
dabigatran etexilate
rivaroxaban
apixaban
apixaban
edoxaban
warfarin
factor xa
antithrombins
treatment outcome
renal insufficiency
age factors
Direct current cardioversion (procedure)
myocardial infarction
surgical procedures, operative
Factor Xa Inhibitors
anticoagulotherapy
Dabigatran
Rivaroxaban
pyridines
pyrazoles
pyridones
thiazoles

---
http://www.has-sante.fr/portail/jcms/c_1700943/fr/point-sur-lutilisation-des-nouveaux-anticoagulants-oraux
2013
false
France
French
anticoagulotherapy
Rivaroxaban
Dabigatran
anticoagulants
administration, oral
dabigatran etexilate
rivaroxaban
apixaban
apixaban
thromboembolism
thromboembolism
product surveillance, postmarketing
hemorrhage
practice guidelines as topic
drug information
pyrazoles
pyridones

---
https://smf.swisshealthweb.ch/fr/article/doi/fms.2013.01679/
2013
false
Switzerland
French
anticoagulotherapy
Rivaroxaban
Dabigatran
dabigatran etexilate
anticoagulants
administration, oral
rivaroxaban
apixaban
apixaban
patient compliance
surgical procedures, operative
venous thromboembolism
atrial fibrillation
thromboembolism
renal insufficiency
perioperative period
hemorrhage
risk management
journal article
pyrazoles
pyridones

---
https://ansm.sante.fr/uploads/2021/03/12/f6f2d53a601a3f25c5e0eb84dff9dd28.pdf
2013
false
France
French
Factor Xa Inhibitors
anticoagulotherapy
Rivaroxaban
Rivaroxaban
Dabigatran
Dabigatran
anticoagulants
anticoagulants
anticoagulants
administration, oral
hemorrhage
risk
continuity of patient care
thrombin
factor xa
apixaban
examination questions
patient education handout
drug information
rivaroxaban
apixaban
dabigatran etexilate
pyrazoles
pyridones

---
http://www.has-sante.fr/portail/jcms/c_1626282/en/fibrillation-auriculaire-non-valvulaire-quelle-place-pour-les-anticoagulants-oraux-non-antivitamine-k-apixaban-eliquis-dabigatran-pradaxa-et-rivaroxaban-xarelto-fiche-bum
http://www.has-sante.fr/portail/jcms/c_1626266/en/bon-usage-anticoagulants-oraux-non-avk
2013
true
France
French
antivitamins K
anticoagulotherapy
Rivaroxaban
Dabigatran
atrial fibrillation
anticoagulants
administration, oral
apixaban
dabigatran etexilate
apixaban
guidelines for drug use
rivaroxaban
thromboembolism
hemorrhage
anticoagulants
antivitamins K
risk factors
drug interactions
patient compliance
evaluation of the transparency committee
indenes
4-hydroxycoumarins
vitamin K
pyrazoles
pyridones

---
https://minerva-ebp.be/fr/analyses-en-ligne/153
2013
false
false
minerva-ebm.be
Belgium
French
Dutch
recurrence
Dabigatran
critical appraisal or critical reading
secondary prevention
venous thromboembolism
antithrombins
dabigatran etexilate
administration, oral
hemorrhage

---
http://www.has-sante.fr/portail/upload/docs/application/pdf/2012-03/pradaxa_15022012_avis_ct10749.pdf
http://www.has-sante.fr/portail/jcms/c_1221597/pradaxa
2012
false
France
French
Dabigatran
Dabigatran
thrombin
aged
treatment outcome
clinical trials, phase iii as topic
antithrombins
insurance, health, reimbursement
pharmacovigilance
hemorrhage
administration, oral
stroke
dabigatran etexilate
embolism
antithrombins
atrial fibrillation
risk factors
adult
dabigatran etexilate mesylate
dabigatran etexilate mesylate
evaluation of the transparency committee

---
https://www.healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2012/16387a-fra.php
https://www.healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2012/16385a-fra.php
2012
false
Canada
French
English
Cardiotoxicity
Dabigatran
Contraindications, Procedure
dabigatran etexilate
administration, oral
antithrombins
heart valve prosthesis
heart valve diseases
clinical trials, phase ii as topic
thromboembolism
stroke
myocardial infarction
pharmacovigilance note
guidelines for drug use
dabigatran etexilate mesylate
thrombosis
Contraindications, Drug

---
http://www.has-sante.fr/portail/jcms/c_1250198/pradaxa-dabigatran-anticoagulant-oral
2012
false
France
French
guidelines for drug use
evaluation of the transparency committee
Dabigatran
Dabigatran
administration, oral
dabigatran etexilate mesylate
dabigatran etexilate mesylate
atrial fibrillation
stroke
embolism
antithrombins
antithrombins
thrombin
dabigatran etexilate
adult
aged
treatment outcome
clinical trials, phase iii as topic
randomized controlled trials as topic

---
https://www.healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2012/15855a-fra.php
https://www.healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2012/17031a-fra.php
2012
false
Canada
English
French
Dabigatran
Dabigatran
Contraindications, Procedure
antithrombins
dabigatran etexilate
administration, oral
renal insufficiency
kidney function tests
antithrombins
thrombin
hemorrhage
adult
aged
risk assessment
heart valve prosthesis
mitral valve stenosis
rheumatic heart disease
dabigatran etexilate mesylate
dabigatran etexilate mesylate
guidelines for drug use
pharmacovigilance note
patient education handout
Contraindications, Drug

---
https://www.ema.europa.eu/medicines/human/EPAR/Pradaxa
2012
false
United Kingdom
French
English
syndication feed
Dabigatran
Dabigatran
drug approval
drug labeling
drug evaluation
treatment outcome
capsules
administration, oral
adult
postoperative complications
venous thrombosis
arthroplasty, replacement, hip
arthroplasty, replacement, knee
aged
drug interactions
pregnancy
prodrugs
drug evaluation, preclinical
dabigatran etexilate
antithrombins
antithrombins
dabigatran etexilate mesylate
dabigatran etexilate mesylate
drug evaluation
summary of product characteristics
package leaflet

---
https://www.inesss.qc.ca/publications/repertoire-des-publications/publication/guide-dusage-optimal-sur-lanticoagulotherapie-par-le-dabigatran-pradaxamc-dans-le-traitement-de-la-fibrillation-auriculaire.html
2012
false
Canada
French
anticoagulotherapy
Dabigatran
Dabigatran
atrial fibrillation
anticoagulants
warfarin
drug interactions
hemorrhage
anticoagulants
dabigatran etexilate mesylate
dabigatran etexilate
dabigatran etexilate mesylate
guidelines for drug use
comparative study

---
https://www.healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2011/14100a-fra.php
https://www.healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2011/14655a-fra.php
2011
false
Canada
French
English
pharmacovigilance note
Dabigatran
dabigatran etexilate mesylate
canada
medication errors
risk
platelet aggregation inhibitors
anticoagulants
administration, oral
dabigatran etexilate
clopidogrel
clopidogrel bisulfate
ticlopidine
Clopidogrel

---
https://pgtmsite.files.wordpress.com/2024/01/dabigatran_fa_20110426_edit_0505.pdf
2011
Canada
drug information
Valvular Heart Disorder
Patient
Atrial Fibrillation, CTCAE
Atrial Fibrillation
Dabigatran
has patient
Dabigatran
atrial fibrillation
patients
heart valve diseases
atrial fibrillation

---
https://www.cadth.ca/sites/default/files/pdf/R0004_Anticoagulants_for_Atrial_Fibrillation_cetap_f.pdf
2010
true
Canada
French
Rivaroxaban
Dabigatran
stroke
atrial fibrillation
administration, oral
canada
treatment outcome
Evidence-Based medicine
dabigatran etexilate
anticoagulants
drug evaluation
rivaroxaban
journal article

---
https://minerva-ebp.be/fr/article/302
2010
false
false
minerva-ebm.be
Belgium
French
Dutch
Dabigatran
Dabigatran
atrial fibrillation
warfarin
anticoagulants
stroke
embolism
warfarin
anticoagulants
warfarin
dabigatran etexilate
treatment outcome
critical appraisal or critical reading
comparative study

---
http://www.cbip.be/Folia/Index.cfm?FoliaWelk=F37F03B
2010
false
Belgium
French
anticoagulotherapy
Rivaroxaban
Dabigatran
venous thromboembolism
anticoagulants
administration, oral
dabigatran etexilate
postoperative complications
orthopedic procedures
treatment outcome
dabigatran etexilate mesylate
journal article
rivaroxaban

---
http://www.john-libbey-eurotext.fr/fr/revues/medecine/nro/e-docs/00/04/52/EF/article.phtml
2009
false
France
French
anticoagulotherapy
Dabigatran
Dabigatran
anticoagulants
atrial fibrillation
warfarin
hemorrhage
warfarin
atrial fibrillation
warfarin
dabigatran etexilate
comparative study
journal article

---
https://pgtmsite.files.wordpress.com/2024/01/dabigatran_eval_somm_20090226.pdf
2009
Canada
drug information
orthopedics
Orthopedics
Dabigatran
Dabigatran
operative procedure, nos
orthopedic surgery

---
https://hpr-rps.hres.ca/reg-content/sommaire-motif-decision-detailOne.php?lang=fr&linkID=SBD00111
2008
false
Canada
French
English
Dabigatran
Dabigatran
administration, oral
dabigatran etexilate
anticoagulants
anticoagulants
venous thromboembolism
prodrugs
prodrugs
antithrombins
arthroplasty
postoperative complications
drug evaluation, preclinical
drug interactions
treatment outcome
dabigatran etexilate mesylate
dabigatran etexilate mesylate
drug information

---
http://www.has-sante.fr/portail/jcms/c_743928/synthese-d-avis-pradaxa-ct-5528
http://www.has-sante.fr/portail/jcms/c_698139/pradaxa
2008
false
France
French
evaluation of the transparency committee
Dabigatran
Dabigatran
thrombin
dabigatran etexilate
administration, oral
insurance, health, reimbursement
treatment outcome
antithrombins
antithrombins
adult
venous thromboembolism
postoperative complications
arthroplasty, replacement, hip
arthroplasty, replacement, knee
randomized controlled trials as topic
dabigatran etexilate mesylate
dabigatran etexilate mesylate
guidelines for drug use

---
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05/05/2025


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