Platelet Factor 4

Preferred Label : Platelet Factor 4;

NCIt synonyms : PF4; Small Inducible Cytokine B4; Chemokine (C-X-C motif) Ligand 4; Small Inducible Cytokine Subfamily B, Member 4; Iroplact; C-X-C Motif Chemokine 4; Platelet Factor-4; Small-Inducible Cytokine B4; Oncostatin-A; CXCL4;

NCIt definition : Platelet factor 4 (101 aa, 11 kDa) is encoded by the human PF4 gene. This protein is involved in the negative regulation of endothelial cell proliferation, the chemotaxis of neutrophils and monocytes and the positive regulation of blood coagulation.;

NCIt note : Platelet factor 4 is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its heparin-binding ability causes the neutralization of heparin-like molecules on the endothelial surface of blood vessels, which leads to the inhibition of local antithrombin III activity and promotes coagulation. PF4 is a strong chemoattractant for neutrophils and fibroblasts, which indicates a potential role in inflammation and wound repair. (OMIM);

Details

Origin ID

C20811;

UMLS CUI

C3887656;

Currated CISMeF NLP mapping
- Platelet factor 4 [LOINC component]
- Platelet factor 4 [MedDRA Preferred Term]
- platelet factor 4 [MeSH Descriptor]
- platelet factor 4 [MeSH concept]
- platelet factor 4 [SNOMED Notion]
False automatic mappings
- Platelet factor 4 (substance) [SNOMED CT concept]
- platelet factor 4 (47-70) [MeSH concept]
- platelet factor 4 (47-70) [MeSH Supplementary Concept]
- platelet factor 4 (59-70) [MeSH concept]
- platelet factor 4 (59-70) [MeSH Supplementary Concept]
OMIM relation
- Platelet factor 4 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CXC Cytokine Gene [NCIt concept]
- Cytokine Gene [NCIt concept]
- PF4 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Central Nervous System [NCIt concept]
- Epithelial Cell [NCIt concept]
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Signaling Protein [NCIt concept]
gene_product_is_element_in_pathway
- Chemokine Signaling Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Chemotactic Process [NCIt concept]
- Coagulation Process [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Immune Response Process [NCIt concept]
- Immunoregulation [NCIt concept]
- Inflammatory Response [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Leukocyte Trafficking [NCIt concept]
- Maturation [NCIt concept]
- Wound Repair [NCIt concept]

Keyword's position in hierarchy(ies) :

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