Iroplact - CISMeF

Preferred Label : Iroplact;

NCIt synonyms : Recombinant CXCL4; rhPF4; rPF4; Therapeutic Platelet Factor 4;

NCIt related terms : Recombinant Platelet Factor 4;

NCIt definition : A recombinant form of the endogenous chemokine platelet factor 4 with potential antiangiogenesis and antineoplastic activities. As a heparin-binding tetramer, iroplact inhibits growth factor-stimulated endothelial cell proliferation, migration, and angiogenesis; it has been shown that this agent inhibits fibroblast growth factor 2 (FGF2) angiogenic activity downstream from the FGF2 receptor. Its activity is antagonized by heparin. Recombinant platelet factor 4 may also directly inhibit the proliferation of some tumor cell types.;

UNII : T381WW8L8Y;

CAS number : 37270-94-3;

NSC code : 671662;

Codes from synonyms : NSC0671662;

Details

Origin ID

C2251;

UMLS CUI

C3887655;

Currated CISMeF NLP mapping
- Platelet factor 4 [LOINC component]
- Platelet factor 4 [MedDRA Preferred Term]
- platelet factor 4 [MeSH Descriptor]
- platelet factor 4 [MeSH concept]
- platelet factor 4 [SNOMED Notion]
False automatic mappings
- Platelet factor 4 (substance) [SNOMED CT concept]
- platelet factor 4 (47-70) [MeSH concept]
- platelet factor 4 (47-70) [MeSH Supplementary Concept]
- platelet factor 4 (59-70) [MeSH concept]
- platelet factor 4 (59-70) [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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