Membrane Cofactor Protein

Preferred Label : Membrane Cofactor Protein;

NCIt synonyms : Antigen Identified By Monoclonal Antibody TRA-2-10; Measles Virus Receptor; CD46 Antigen; Complement Membrane Cofactor Protein; Antigen Defined By Monoclonal Antibody TRA-2-10; Trophoblast Leucocyte Common Antigen; Trophoblast-Lymphocyte Cross-Reactive Antigen; TLX; Trophoblast Leukocyte Common Antigen;

NCIt definition : Membrane cofactor protein (392 aa, 44 kDa) is encoded by the human CD46 gene. This protein is involved in the classical complementation pathway, pathogen binding, fertilization and T-cell differentiation.;

NCIt note : Membrane cofactor protein is a receptor for adenovirus subgroup B2 and Ad3, cultured measles virus and herpesvirus 6, and may also bind the pathogenic bacteria Neisseria and Streptococcus pyogenes. (UniProt);

Details

Origin ID

C126979;

UMLS CUI

C1505678;

Automatic exact mappings (from CISMeF team)
- CD46 molecule [ORDO Gene]
- CD46 molecule [HGNC gene]
- Cd46 antigen [OMIM gene]
- Lymphocyte antigen CD46 (substance) [SNOMED CT concept]
- Membrane Cofactor Protein [MeSH Descriptor]
- Membrane Cofactor Protein [MeSH concept]
- Nuclear receptor subfamily 2, group e, member 1 [OMIM gene]
- membrane cofactor protein [SNOMED Notion]
- trophoblast-lymphocyte cross-reactive antigens [MeSH concept]
- trophoblast-lymphocyte cross-reactive antigens [MeSH Supplementary Concept]
OMIM relation
- Cd46 antigen [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- CD46 protein, human [MeSH Supplementary Concept]
- CD46 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CD46 Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Viral Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Sushi Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Complement and Coagulation Cascade [NCIt concept]
gene_product_plays_role_in_biological_process
- Immunoregulation [NCIt concept]
- Ligand Binding [NCIt concept]
- Negative Regulation of Complement Activation [NCIt concept]
- T-Cell Differentiation [NCIt concept]
is_target
- Adenovirus 5/F35-Human Guanylyl Cyclase C-PADRE [NCIt concept]
- Anti-CD46 Antibody-drug Conjugate FOR46 [NCIt concept]
- Anti-CD46 Monoclonal Antibody YS5 [NCIt concept]
- Carcinoembryonic Antigen-Expressing Measles Virus [NCIt concept]
- Oncolytic Measles Virus Encoding Thyroidal Sodium Iodide Symporter [NCIt concept]
- Zirconium Zr 89-DFO-YS5 [NCIt concept]

Keyword's position in hierarchy(ies) :

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