Preferred Label : Zirconium Zr 89-DFO-YS5;
NCIt synonyms : 89Zr DFO-YS5; Zr 89-DFO-YS5; (89)Zr-DFO-YS5; 89Zr-DFO-YS5;
NCIt definition : A radioimmunoconjugate containing YS5, a human immunoglobulin G1 (IgG1) monoclonal
antibody directed against the cell surface antigen cluster of differentiation 46 (CD46;
membrane cofactor protein; MCP), and linked, via the chelator desferrioxamine (DFO),
to the radioisotope zirconium Zr 89 (Zr89), with potential diagnostic properties upon
positron emission tomography (PET) imaging. Upon administration, the monoclonal antibody
moiety of zirconium Zr 89-DFO-YS5 specifically targets and binds to a conformational
epitope formed within Sushi domains (complement control protein repeats; CCPs) 1 and
2 on the immune modulatory receptor CD46 expressed on certain tumor cells. Upon binding,
internalization and PET, CD46-expressing tumor cells can be imaged and assessed. The
conformational epitope on CD46 is highly expressed in multiple tumor cell types while
minimally expressed or absent in normal, healthy tissues. CD46 plays a key role in
the negative regulation of innate immunity.;
NCI Metathesaurus CUI : CL1773757;
Origin ID : C185465;
UMLS CUI : C5669917;
Semantic type(s)
- concept_is_in_subset
- has_target
