Preferred Label : Carcinoembryonic Antigen-Expressing Measles Virus;
NCIt synonyms : MV-CEA;
NCIt definition : An attenuated oncolytic Edmonston (Ed) strain of measles virus (MV) encoding the soluble
extracellular N-terminal domain of human carcinoembryonic antigen (CEA) (MV-CEA) with
potential antineoplastic activity. The cellular receptor of MV is human CD46 antigen,
a type 1 integral membrane glycoprotein found on nearly all human tissues and overexpressed
on many cancer cell types. Mediated through CD46, both haemagglutinin and fusion glycoproteins
of MV are required for the attachment to and fusion of host cell membranes, thereby
leading to syncytia and cell lysis. The expressed CEA, a tumor associated antigen,
can be detected in serum and used as a sensitive marker to monitor viral gene expression
in order to easily optimize individual therapy. Compared to wild-type MV, the Ed strain
of MV has a lower affinity for the MV receptor signaling lymphocyte-activation molecule
(CD150), mainly expressed in B- and T-lymphocytes, but a higher affinity for CD46.;
Origin ID : C64775;
UMLS CUI : C1831991;
Semantic type(s)
- concept_is_in_subset
- has_target
