NCIt definition : A human immunoglobulin G1 (IgG1) monoclonal antibody directed against the cell surface
antigen cluster of differentiation 46 (CD46; membrane cofactor protein; MCP) that
can potentially be used as the antibody moiety of a radioimmunoconjugate and/or antibody-drug
conjugate (ADC). Upon administration, anti-CD46 monoclonal antibody YS5 specifically
targets and binds to a conformational epitope formed within Sushi domains (complement
control protein repeats; CCPs) 1 and 2 on the immune modulatory receptor CD46 expressed
on certain tumor cells, and is internalized. The conformational epitope on CD46 is
highly expressed in multiple tumor cell types while minimally expressed or absent
in normal, healthy tissues. CD46 plays a key role in the negative regulation of innate
immunity.;
Semantic type(s)