Preferred Label : Anti-CD46 Antibody-drug Conjugate FOR46;
NCIt synonyms : Antibody-drug Conjugate FOR46; Anti-CD46 ADC FOR46; CD46-ADC FOR46; ADC FOR46;
NCIt definition : An antibody-drug conjugate (ADC) composed of a human monoclonal antibody directed
against the cluster of differentiation 46 (CD46; membrane cofactor protein; MCP) and
conjugated to an as of yet undisclosed cytotoxic payload, with potential antineoplastic
activity. Upon administration, anti-CD46 ADC FOR46 specifically targets and binds
to a specific conformational epitope on the immune modulatory receptor CD46 expressed
on certain tumor cells. Upon binding and internalization, the cytotoxic payload kills
the CD46-expressing tumor cells. The conformational epitope of CD46 is highly expressed
in multiple tumor cell types while minimally expressed or absent in normal, healthy
tissues. FOR46 does not interfere with other CD46-mediated pathways that naturally
occur in normal, healthy tissues.;
Molecule name : FOR 46; FOR-46;
NCI Metathesaurus CUI : CL563108;
Origin ID : C156416;
UMLS CUI : C4744807;
Semantic type(s)
- concept_is_in_subset
- has_target
