Carboxypeptidase B2

Preferred Label : Carboxypeptidase B2;

NCIt synonyms : Thrombin-Activable Fibrinolysis Inhibitor; EC 3.4.17.20; TAFI; Carboxypeptidase U; Thrombin-Activatable Fibrinolysis Inhibitor; Plasma Carboxypeptidase B; CPB2; pCPB;

NCIt definition : Carboxypeptidase B2 (423 aa, 48 kDa) is encoded by the human CPB2 gene. This protein is involved in the cleavage of C-terminal arginine or lysine residues from biologically active peptides and partially degraded fibrin.;

NCIt note : The carboxypeptidase B2 zymogen is stabilized by interactions with the activation peptide. Thrombin mediates the release of the activation peptide and results in increased mobility of a dynamic flap in the protein structure. This leads to conformational changes that expose a cryptic thrombin-cleavage site present at Arg-324 and contributes to the short half-life of active carboxypeptidase B2. (UniProt);

Details

Origin ID

C178158;

UMLS CUI

C3710898;

Automatic exact mappings (from CISMeF team)
- Carboxypeptidase B2 [MeSH Descriptor]
- Carboxypeptidase B2 [MeSH concept]
- Carboxypeptidase U (substance) [SNOMED CT concept]
- Carboxypeptidase b1, tissue [OMIM gene]
- Carboxypeptidase b2, plasma [OMIM gene]
- Thrombin activatable fibrinolysis inhibitor [LOINC component]
- carboxypeptidase B2 [HGNC gene]
- curli [GO term]
- pentachlorophenol monooxygenase activity [GO term]
- pulmonary wedge pressure [MeSH Descriptor]
OMIM relation
- Carboxypeptidase b2, plasma [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- CPB2 protein, human [MeSH Supplementary Concept]
- CPB2 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CPB2 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Metallopeptidase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_expressed_in_tissue
- Plasma [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_chemical_classification
- Metalloprotein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Metal Binding Site [NCIt concept]
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_biomarker_type
- Metastasis and Aggressiveness Marker [NCIt concept]
gene_product_is_element_in_pathway
- Complement and Coagulation Cascade [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Metal Ion Binding [NCIt concept]
- Proteolytic Processing [NCIt concept]
- Regulation of Proteolysis [NCIt concept]
- Wound Repair [NCIt concept]
is_target
- TAFIa Inhibitor DS-1040b [NCIt concept]

Keyword's position in hierarchy(ies) :

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