Preferred Label : TAFIa Inhibitor DS-1040b;
NCIt synonyms : Carboxypeptidase B2 Inhibitor DS-1040b; Carboxypeptidase U Inhibitor DS-1040b; Inhibitor of Activated Thrombin Activatable Fibrinolysis Inhibitor DS-1040b; CPB2 Inhibitor DS-1040b; (2S)-5-amino-2-[[1-(4-methylcyclohexyl)imidazol-4-yl]methyl]pentanoic Acid;
NCIt definition : An inhibitor of the activated form of thrombin-activatable fibrinolysis inhibitor
(TAFIa; carboxypeptidase B2; CPB2), with potential fibrinolytic activity. Upon DS-1040
infusion, this agent binds to and inhibits TAFIa. This abrogates TAFIa-mediated inhibition
of fibrinolysis. This induces fibrinolysis, degrades fibrin clots and prevents thrombus
formation. TAFIa, a carboxypeptidase that is activated by thrombin, cleaves C-terminal
amino acid residues from fibrin, which prevents binding and activation of plasminogen
and inhibits plasmin-mediated fibrinolysis.;
Molecule name : DS-1040b; DS-1040; DS 1040;
NCI Metathesaurus CUI : CL551154;
Origin ID : C148637;
UMLS CUI : C4725178;
Semantic type(s)
- concept_is_in_subset
- has_target
