Carboxypeptidase B2

Preferred Label : Carboxypeptidase B2;

MeSH definition : A carboxypeptidase that removes C-terminal lysine or arginine from peptides and proteins. Carboxypeptidase B2 (CPB2) is released into the circulation as a proenzyme which is activated by the THROMBIN-THROMBOMODULIN complex. Activated CPB2 is involved in modulating a variety of processes by cleaving and inactivating various circulating proteins and peptides that are its substrates including FIBRIN; KININS; and ANAPHYLATOXINS.;

MeSH synonym : carboxypeptidase r; thrombin activatable fibrinolysis inhibitor; thrombin-activatable fibrinolysis inhibitor; arginine carboxypeptidase; Thrombin-Activatable Fibrinolysis Inhibitor (TAFI); Carboxypeptidase B2, Plasma; Plasma Carboxypeptidase B2; Carboxypeptidase U;

CISMeF acronym : tafi;

Related MeSH term : procarboxypeptidase U; Plasma Procarboxypeptidase B;

Registry Number MeSH : EC 3.4.17.20;

Wikipedia link : https://en.wikipedia.org/wiki/Carboxypeptidase u;

Is substance : O;

UNII : EC 3.4.17.20;

Details

Origin ID

D025901;

UMLS CUI

C0255161;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Record concept(s)
- Carboxypeptidase B2 [MeSH concept]
- procarboxypeptidase U [MeSH concept]
Related MeSH Supplementary Concept(s)
- CPB2 protein, human [MeSH Supplementary Concept]
- Cpb2 protein, mouse [MeSH Supplementary Concept]
- Cpb2 protein, rat [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Carboxypeptidase U (substance) [SNOMED CT concept]
- Thrombin activatable fibrinolysis inhibitor [LOINC component]

Keyword's position in hierarchy(ies) :

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