Tissue Factor - CISMeF

Preferred Label : Tissue Factor;

NCIt synonyms : Factor III; CD142 Antigen; F3; TF; Tissue Thromboplastin; F3 Protein; Thromboplastin; Coagulation Factor III; Coagulation Factor-III;

NCIt definition : Tissue factor (295 aa, 33 kDa) is encoded by the human F3 gene. This protein is involved in both binding to coagulation factor VII and the initiation of blood coagulation.;

NCIt note : Tissue factor exists as at least two isoforms that are produced by alternative splicing. Isoform 1 is a transmembrane form and isoform 2 is a secreted form that is missing the transmembrane domain. (UniProt);

Details

Origin ID

C17197;

UMLS CUI

C4048299;

Currated CISMeF NLP mapping
- coagulation factor iii [SNOMED Notion]
- factor III(Glc) [MeSH concept]
- factor III(Glc) [MeSH Supplementary Concept]
- factor III(lac) [MeSH concept]
- factor III(lac) [MeSH Supplementary Concept]
OMIM relation
- Coagulation factor III [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Coagulation Factor Gene [NCIt concept]
- F3 Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Coagulation Factor [NCIt concept]
gene_product_has_chemical_classification
- Glycoprotein [NCIt concept]
- Phosphoprotein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
gene_product_is_biomarker_type
- Disease Marker [NCIt concept]
gene_product_is_element_in_pathway
- Complement and Coagulation Cascade [NCIt concept]
- Extrinsic Prothrombin Activation Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Coagulation Process [NCIt concept]
- Ligand Binding [NCIt concept]
is_target
- Anti-TF Antibody-drug Conjugate MRG004A [NCIt concept]
- Anti-TF Monoclonal Antibody ALT-836 [NCIt concept]
- Anti-Tissue Factor Monoclonal Antibody MORAb-066 [NCIt concept]
- Anti-tissue Factor Antibody-drug Conjugate XB002 [NCIt concept]
- Factor VII-targeting Immunoconjugate Protein ICON-1 [NCIt concept]
- Tisotumab Vedotin [NCIt concept]

Keyword's position in hierarchy(ies) :

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