NCIt definition : An antibody-drug conjugate (ADC) comprised of a monoclonal antibody against human
tissue factor (TF) conjugated via a linker to an auristatin payload, with potential
antineoplastic activity. Upon administration of anti-TF ADC XB002, the anti-TF antibody
moiety binds to cell surface TF and is internalized. After internalization of the
agent, the auristatin moiety is released. It then binds to tubulin and inhibits its
polymerization, which results in G2/M phase arrest and induces apoptosis of TF-expressing
tumor cells. TF, a transmembrane protein and an initiator of the coagulation cascade,
is overexpressed in many tumor cells and tumor-resident endothelial cells. Expression
of TF is correlated with metastasis, angiogenesis, tumor cell growth and tumor-associated
thrombosis. The anti-TF antibody in XB002 does not affect coagulation.;
Currated CISMeF NLP mapping