Preferred Label : Factor VII-targeting Immunoconjugate Protein ICON-1;
NCIt synonyms : FVII Modified Conjugate ICON-1; FVII-targeting Immunoconjugate Protein ICON-1; Human Immuno-conjugate 1; VII-Fc Fusion Protein ICON-1;
NCIt definition : A human immunoconjugate (ICON) fusion protein composed of a modified version of human
factor VII (FVII) which targets tissue factor (TF) that is fused to the Fc domain
of the human immunoglobulin G1, with potential anti-thrombotic and antineoplastic
activities. Acting in a similar manner as plasma FVII, the natural ligand of TF, ICON-1
targets and binds to TF expressed on neovascular endothelia, thereby preventing TF-mediated
signaling pathways, and leading to the initiation of an immune response and the destruction
of neovascular tissue. This prevents angiogenesis, inflammation and blood coagulation.
Upon intravitreal administration, ICON-1 may block TF-induced angiogenesis and treat
wet age-related macular degeneration (AMD) and ocular melanoma. TF, a naturally occurring
glycoprotein in humans, regulates blood clotting, angiogenesis, and inflammation.;
Molecule name : ICON-1;
NCI Metathesaurus CUI : CL512298;
Origin ID : C129313;
UMLS CUI : C4287686;
Semantic type(s)
- concept_is_in_subset
- has_target
