Preferred Label : Anti-TF Antibody-drug Conjugate MRG004A;
NCIt synonyms : Anti-TF ADC MRG004A;
NCIt definition : An antibody-drug conjugate (ADC) comprised of a monoclonal antibody against human
tissue factor (TF) conjugated, via a protease-cleavable BCN-valyl-citrulline linker,
with monomethyl auristatin E (MMAE), an auristatin derivative and potent microtubule
disrupting agent, with potential antiangiogenic, anticoagulant and antineoplastic
activities. Upon administration of anti-TF ADC MRG004A, the monoclonal antibody moiety
binds to cell surface TF and is internalized. After internalization of the agent,
the MMAE moiety is released by proteolytic cleavage. It then binds to tubulin and
inhibits its polymerization, which results in G2/M phase arrest and apoptosis. TF,
a transmembrane protein and initiator of the coagulation cascade, is overexpressed
in many tumor cells and tumor-resident endothelial cells. Expression of TF is correlated
with metastasis, angiogenesis, tumor cell growth and tumor-associated thrombosis.;
Molecule name : MRG-004A; MRG 004A;
NCI Metathesaurus CUI : CL1662928;
Origin ID : C180589;
UMLS CUI : C5556481;
Semantic type(s)
- concept_is_in_subset
- has_target
