Preferred Label : Prostaglandin G/H Synthase 1;

NCIt synonyms : EC 1.14.99.1; Prostaglandin-Endoperoxide Synthase; COX3; Cyclooxygenase 3; Cyclooxygenase-1; PTGS; Prostaglandin G/H Synthase and Cyclooxygenase; PGHS-1; COX-1; COX; Prostaglandin H2 Synthase; PHS1; Cyclooxygenase; PTGS1; Fatty Acid Cyclooxygenase; Prostaglandin-Endoperoxide Synthase-1; COX1; Cyclo-Oxygenase-1; PGH Synthase; PGH Synthase 1; Prostaglandin H2 Synthase 1; PHS 1; Prostaglandin-Endoperoxide Synthase 1;

NCIt definition : Prostaglandin G/H synthase 1 (599 aa, 69 kDa) is encoded by the human PTGS1 gene. This protein plays a role in vasoconstriction, blood pressure homeostasis and prostaglandin metabolism.;

NCIt note : COX-1 is known to be present in most tissues as the housekeeper enzyme, maintains normal gastric mucosa and influences kidney function, while COX-2 is inducible by inflammation. They share 60% homology. The expression of Cox-1 is induced by cytokines and mitogens, hence it is likely to play a role in inflammatory diseases such as rheumatoid arthritis. It contains one EGF-like domain. Both isoforms have the same affinity to convert arachidonic acid to prostaglandin. COX-1. Both forms of COX proteins are membrane associated heme proteins containing cyclooxygenase and peroxidase activities. These enzymes are targets of NSAID (Non steroidal anti-inflammatory drugs) such as aspirin.;

Details


Keyword's position in hierarchy(ies) : arborescence

Main resources

You can consult :


https://pgtmsite.files.wordpress.com/2024/01/coxibs_innocuitecardiovascualire_pgtm_20050407.pdf
2005
Canada
drug information
Prostaglandin G/H Synthase 1
cardiovascular system, nos
Cardiovascular
cyclooxygenase 2

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24/04/2024


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