Ketorolac - CISMeF

Preferred Label : Ketorolac;

NCIt definition : A synthetic pyrrolizine carboxylic acid derivative with anti-inflammatory, analgesic, and antipyretic activities. Ketorolac non-selective inhibits the enzymes cyclooxygenase 1 (COX-1) and COX-2. The inhibition of COX-2, up-regulated at sites of inflammation, prevents conversion of arachidonic acid to pro-inflammatory prostaglandins. The inhibition of COX-1 by this agent prevents the normal steady-state production of prostaglandins that play housekeeping roles in the protection of the gastrointestinal tract, the regulation of renal blood flow, and platelet aggregation. As a result, the inhibition of COX-1 may be associated with gastrointestinal toxicity, nephrotoxicity, and the inhibition of platelet aggregation.;

UNII : YZI5105V0L;

InChIKey : OZWKMVRBQXNZKK-UHFFFAOYSA-N;

CAS number : 74103-06-3;

Chemical formula : C15H13NO3;

Codes from synonyms : CDR0000045305; 30559;

Details

Origin ID

C1219;

UMLS CUI

C0073631;

Currated CISMeF NLP mapping
- Ketorolac [ICD-11 Extension code]
- Ketorolac [ICHI extension code]
- Ketorolac [SMS substance]
- Ketorolac [LOINC component]
- Ketorolac (substance) [SNOMED CT concept]
- ketorolac [MeSH Descriptor]
- ketorolac [MeSH concept]
See also inter- (CISMeF)
- Product containing ketorolac (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Ketorolac [ICD-11 Extension code]
- Ketorolac [LOINC component]
- Ketorolac (substance) [SNOMED CT concept]
- Product containing ketorolac (medicinal product) [SNOMED CT concept]
- ketorolac [ATC Code]
- ketorolac [ATC Code]
- ketorolac [MeSH Descriptor]
- ketorolac [MeSH concept]
Validated automatic mappings to BTNT
- ketorolac [ATC Code]
- ketorolac [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_salt_form
- Ketorolac Tromethamine [NCIt concept]
has_target
- Prostaglandin G/H Synthase 1 [NCIt concept]
- Prostaglandin G/H Synthase 2 [NCIt concept]
is_free_acid_or_base_form_of
- Ketorolac Tromethamine [NCIt concept]

Keyword's position in hierarchy(ies) :

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