Preferred Label : Ketorolac Tromethamine;
NCIt definition : The tromethamine salt of ketorolac, a synthetic pyrrolizine carboxylic acid derivative
with anti-inflammatory, analgesic and antipyretic properties. Ketorolac tromethamine,
a non-selective inhibitor of the cyclooxygenases (COX), inhibits both COX-1 and COX-2
enzymes. This agent exerts its anti-inflammatory effect by preventing conversion of
arachidonic acid to prostaglandins at inflammation site mediated through inhibition
of COX-2, which is undetectable in most tissues but is up-regulated at the inflammation
sites. Since COX-1 is expressed virtually in all tissues, inhibition of COX-1 enzyme
by this agent prevents normal state production of prostaglandins, which plays housekeeping
roles in the protection of the gastrointestinal tract, regulating renal blood flow,
and functioning in platelet aggregation. As a result, inhibition of COX-1 is usually
associated with adverse effects such as gastrointestinal toxicity and nephrotoxicity.;
UNII : 4EVE5946BQ;
InChIKey : BWHLPLXXIDYSNW-UHFFFAOYSA-N;
CAS number : 74103-07-4;
Drug name : Toradol;
Chemical formula : C15H13NO3.C4H11NO3;
Origin ID : C61798;
UMLS CUI : C0064326;
Semantic type(s)
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_salt_form_of
