" /> Prostaglandin G/H Synthase 2 - CISMeF





Preferred Label : Prostaglandin G/H Synthase 2;

NCIt synonyms : Prostaglandin G/H Synthase and Cyclooxygenase; Cyclooxygenase 2; PGHS2; Cyclooxygenase-2; PHS II; COX-2; COX2; Prostaglandin H2 Synthase 2; PTGS; Prostaglandin-Endoperoxide Synthase-2; EC 1.14.99.1; PGHS-2; PGH Synthase 2; Cyclooxygenase; Cyclo-Oxygenase-2; PTGS2; Prostaglandin-Endoperoxide Synthase; Prostaglandin-Endoperoxide Synthase 2; Glucocorticoid-Regulated Inflammatory Prostaglandin G/H Synthase;

NCIt definition : Prostaglandin G/H synthase 2 (604 aa, 69 kDa) is encoded by the human PTGS2 gene. This protein plays a role in prostaglandin metabolism.;

Alternative definition : NCI-GLOSS: An enzyme that speeds up the formation of substances that cause inflammation and pain. It may also cause tumor cells to grow. Some tumors have high levels of COX-2 and blocking its activity may reduce tumor growth.;

NCIt note : A rate-limiting enzyme in the conversion of arachidonic acid to prostaglandins, COX-2 is expressed in cells involved in inflammatory processes and has been implicated in tumor promotion as well as a negative prognosis. COX-2 is expressed in 50% of pancreatic tumors. Anti-inflammatory glucocorticoids are potent inhibitors of cyclooxygenase. Inhibition or lack of COX-2 reduces tumor growth and blocks angiogenesis. Aspirin and etodolac, both COX-2 inhibitors, inhibit growth of pancreatic cancer cell lines. (from Cancer 2001. 91:333, Medscape, and OMIM 600262);

Codes from synonyms : CDR0000589402; CDR0000589403; CDR0000559451;

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29/04/2024


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