Preferred Label : Anti-TGF-beta 1/Anti-COX-2 siRNAs STP707;
NCIt synonyms : Anti-TGF-beta 1/COX-2 siRNAs STP707; Anti-TGF-beta 1/Anti-COX-2 siRNA Oligonucleotides STP707;
NCIt definition : A polypeptide nanoparticle (PNP)-based therapeutic comprised of two small interfering
RNA (siRNA) oligonucleotides directed against transforming growth factor-beta 1 (TGF-beta
1) and cyclo-oxygenase-2 (COX-2), with potential immunomodulating and antineoplastic
activities. Upon intravenous administration, anti-TGF-beta 1/anti-COX-2 siRNAs STP707
binds to both TGF-beta 1 and COX-2 messenger RNAs (mRNAs), preventing the translation
and expression of TGF-beta 1 and COX-2 proteins. This inhibits TGF-beta 1-mediated
signaling and abrogates TGF-beta 1-mediated immunosuppression, which may enhance anti-tumor
immunity in the tumor microenvironment (TME) and promote a cytotoxic T-lymphocyte
(CTL)-mediated immune response against tumor cells leading to tumor cell death. The
inhibition of COX-2 prevents COX-2-mediated signaling, which may result in apoptosis
and a reduction in tumor cell proliferation, tumor angiogenesis and metastasis.;
Molecule name : STP 707; STP-707;
NCI Metathesaurus CUI : CL1772557;
Origin ID : C184380;
UMLS CUI : C5666927;
Semantic type(s)
- concept_is_in_subset
- has_target
