Therapeutic Angiotensin-(1-7)

Preferred Label : Therapeutic Angiotensin-(1-7);

NCIt synonyms : Ang 1-7; Therapeutic Angiotensin 1-7;

NCIt related terms : ANGIOTENSIN 1-7;

NCIt definition : A synthetic heptapeptide identical to endogenous angiotensin-(1-7) with vasodilator and antiproliferative activities. Therapeutic angiotensin 1-7 may inhibit cyclooxygenase 2 (COX-2) and the production of proinflammatory prostaglandins and may activate the angiotensin-(1-7) receptor Mas, resulting in diminished tumor cell proliferation. Activation of the angiotensin-(1-7) receptor Mas, a G-protein coupled, seven transmembrane protein, may down-regulate the phosphorylation and activation of Erk1 and Erk2 in the Erk1/Erk2 MAPK signaling pathway. In the renin-angiotensin system, the vasodilating activity of angiotensin- (1-7), hydrolysed from angiotensin II by the type I transmembrane metallopeptidase and carboxypeptidase angiotensin converting enzyme 2 (ACE2) in vivo, counteracts the vasoconstricting activity of angiotensin II.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of several types of cancer. Therapeutic angiotensin-(1-7) is a hormone that is made in the laboratory, and helps control blood pressure. It may stop the growth of some types of cancer cells and may stop the growth of blood vessels needed by tumors to grow. It is a type of antiproliferative agent.;

UNII : IJ3FUK8MOF;

CAS number : 51833-78-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 51833-78-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : TXA-127; TXA 127;

ChEBI ID : CHEBI:55438;

Codes from synonyms : CDR0000559129;

Details

Origin ID

C68962;

UMLS CUI

C0103306;

Currated CISMeF NLP mapping
- Angiotensin (1-7) [LOINC component]
- angiotensin I (1-7) [MeSH Supplementary Concept]
- angiotensin I (1-7) [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Angiotensin (1-7) [LOINC component]
- angiotensin I (1-7) [MeSH concept]
- angiotensin I (1-7) [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
has_target
- Prostaglandin G/H Synthase 2 [NCIt concept]
- Proto-Oncogene Mas [NCIt concept]

Keyword's position in hierarchy(ies) :

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