NCIt definition : A synthetic heptapeptide identical to endogenous angiotensin-(1-7) with vasodilator
and antiproliferative activities. Talfirastide may inhibit cyclooxygenase 2 (COX-2)
and the production of proinflammatory prostaglandins and may activate the angiotensin-(1-7)
receptor Mas, resulting in diminished tumor cell proliferation. Activation of the
angiotensin-(1-7) receptor Mas, a G-protein coupled, seven transmembrane protein,
may down-regulate the phosphorylation and activation of Erk1 and Erk2 in the Erk1/Erk2
MAPK signaling pathway. In the renin-angiotensin system, the vasodilating activity
of angiotensin- (1-7), hydrolysed from angiotensin II by the type I transmembrane
metallopeptidase and carboxypeptidase angiotensin converting enzyme 2 (ACE2) in vivo,
counteracts the vasoconstricting activity of angiotensin II.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of several types of cancer.
Therapeutic angiotensin-(1-7) is a hormone that is made in the laboratory, and helps
control blood pressure. It may stop the growth of some types of cancer cells and may
stop the growth of blood vessels needed by tumors to grow. It is a type of antiproliferative
agent.;