Proto-Oncogene Mas

Preferred Label : Proto-Oncogene Mas;

NCIt synonyms : MAS1; Angiotensin Receptor; MAS1 Gene Product; MAS1 Protein; Mas-Related G Protein-Coupled Receptor A; MAS Proto-Oncogene;

NCIt definition : Proto-oncogene Mas (325 aa, 37 kDa) is encoded by the human MAS1 gene. This protein is involved in angiotensin binding and G protein-coupled receptor signaling.;

NCIt note : A product of the MAS1 Gene, an oncogene isolated from DNA of a human epidermoid carcinoma cell line. Based on its deduced amino acid sequence, the MAS1 gene product contains 7 potential transmembrane domains. The MAS1 protein is, therefore, probably an integral membrane protein. The structure of the MAS oncogene indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural motif, which is described as a '7-transmembrane segment' following the prediction that these hydrophobic segments form membrane-spanning alpha-helices. It is predicted that it would encode a peptide receptor with mitogenic activity which would act through the inositol lipid signaling pathways. Expression in Xenopus oocytes and a transfected mammalian cell line demonstrated that the MAS gene product is a functional angiotensin receptor. (from OMIM);

Details

Origin ID

C17064;

UMLS CUI

C1622222;

Automatic exact mappings (from CISMeF team)
- Mas1 oncogene [OMIM gene]
- peptidase, mitochondrial processing subunit beta [ORDO Gene]
- proto-oncogene proteins c-mas-1 [MeSH concept]
OMIM relation
- Mas1 oncogene [OMIM gene]
See also inter- (CISMeF)
- Angiotensin receptor (substance) [SNOMED CT concept]
- angiotensin receptor site [SNOMED Notion]
- receptors, angiotensin [MeSH Descriptor]
- receptors, angiotensin [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- MAS1 protein, human [MeSH concept]
- MAS1 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- MAS1 Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
- Hormone Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Neuroactive Ligand-Receptor Signaling Pathway [NCIt concept]
- Renin-Angiotensin Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation [NCIt concept]
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Ligand Binding [NCIt concept]
- Morphogenesis [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Therapeutic Angiotensin-(1-7) [NCIt concept]

Keyword's position in hierarchy(ies) :

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