" /> Bardoxolone Methyl - CISMeF





Preferred Label : Bardoxolone Methyl;

NCIt synonyms : CDDO Methyl Ester; 2-cyano-3,12-dioxoolean-1,9-dien-28-oic Acid Methyl Ester; ( )-methyl 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate; CDDO-Me;

NCIt definition : The methyl ester form of bardoxolone, a synthetic triterpenoid compound with potential antineoplastic and anti-inflammatory activities. Bardoxolone blocks the synthesis of inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2), two enzymes involved in inflammation and carcinogenesis. This agent also inhibits the interleukin-1 (IL-1)-induced expression of the pro-inflammatory proteins matrix metalloproteinase-1 (MMP-1) and matrix metalloproteinase-13 (MMP-13) and the expression of Bcl-3; Bcl-3 is an IL-1-responsive gene that preferentially contributes to MMP-1 gene expression.;

UNII : CEG1Q6OGU1;

InChIKey : WPTTVJLTNAWYAO-KPOXMGGZSA-N;

CAS number : 218600-53-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 218600-53-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : RTA 402;

Chemical formula : C32H43NO4;

NSC code : 713200;

Codes from synonyms : 31757;

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12/05/2024


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