Preferred Label : COX-2 Inhibitor ECP-1014;
NCIt synonyms : Cyclooxygenase-2 Inhibitor ECP-1014;
NCIt definition : An orally bioavailable inhibitor of the enzyme cyclooxygenase-2 (COX-2), with potential
analgesic, anti-inflammatory and antineoplastic activities. Upon oral administration,
COX-2 inhibitor ECP-1014 inhibits COX-2, thereby inhibiting the conversion of arachidonic
acid to prostaglandins, including prostaglandin E2 (PGE2). This may reduce pain and
inflammation. The COX-2/PGE 2 pathway may also play an important role in tumor proliferation,
angiogenesis, metastasis and immune suppression in the tumor microenvironment (TME).
COX-2 is overexpressed in certain tumor cells.;
Molecule name : ECP-1014; GIBH-1014; ECP 1014;
NCI Metathesaurus CUI : CL1663615;
Origin ID : C181014;
UMLS CUI : C5556779;
Semantic type(s)
- concept_is_in_subset
- has_target
