" /> Indomethacin - CISMeF





Preferred Label : Indomethacin;

NCIt synonyms : Indometacin; 1-(4-chlorobenzoyl)-5-methoxy- 2-methyl-1-H-indole-3-acetic acid;

NCIt related terms : Indocin;

NCIt definition : A synthetic nonsteroidal indole derivative with anti-inflammatory activity and chemopreventive properties. As a nonsteroidal anti-inflammatory drug (NSAID), indomethacin inhibits the enzyme cyclooxygenase, thereby preventing cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines. This agent also may inhibit the expression of multidrug-resistant protein type 1, resulting in increased efficacies of some antineoplastic agents in treating multi-drug resistant tumors. In addition, indomethacin activates phosphatases that inhibit the migration and proliferation of cancer cells and downregulates survivin, which may result in tumor cell apoptosis. (NCI04);

Alternative definition : NCI-GLOSS: A drug that reduces pain, fever, swelling, and redness. It is also being used to reduce tumor-induced suppression of the immune system and to increase the effectiveness of anticancer drugs. It is a type of nonsteroidal anti-inflammatory drug (NSAID).;

UNII : XXE1CET956;

InChIKey : CGIGDMFJXJATDK-UHFFFAOYSA-N;

CAS number : 53-86-1;

Drug name : Indocin;

Chemical formula : C19H16ClNO4;

NSC code : 77541;

ChEBI ID : CHEBI:49662;

Codes from synonyms : CDR0000045223; NSC0077541; 00069; 271;

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08/05/2025


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