Ibuprofen - CISMeF

Preferred Label : Ibuprofen;

NCIt synonyms : Benzeneacetic Acid, Alpha-methyl-4-(2-methylpropyl)-; p-Isobutylhydratropic Acid;

NCIt related terms : Motrin; Advil; (. -.)-p-Isobutylhydratropic acid;

NCIt definition : A propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. This leads to decreased prostaglandin synthesis, by prostaglandin synthase, the main physiologic effect of ibuprofen. Ibuprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation. (NCI05);

Alternative definition : NCI-GLOSS: A drug used to treat fever, swelling, pain, and redness by preventing the body from making a substance that causes inflammation. It is a type of nonsteroidal anti-inflammatory drug (NSAID).;

UNII : WK2XYI10QM;

InChIKey : HEFNNWSXXWATRW-UHFFFAOYSA-N;

CAS number : 15687-27-1;

Drug name : Motrin;

Chemical formula : C13H18O2;

NSC code : 256857;

ChEBI ID : CHEBI:5855;

Codes from synonyms : CDR0000613511; CDR0000613512; CDR0000613724; NSC0256857; 00803;

Détails

Origin ID

C561;

UMLS CUI

C0020740;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Ibuprofen [ICD-11 Extension code]
- Ibuprofen [LOINC component]
- Ibuprofen (substance) [SNOMED CT concept]
- Product containing ibuprofen (medicinal product) [SNOMED CT concept]
- ibuprofen [ATC Code]
- ibuprofen [ATC Code]
- ibuprofen [ATC Code]
- ibuprofen [ATC Code]
- ibuprofen [ATC Code]
- ibuprofen [Substance BNPC]
- ibuprofen [SNOMED Notion]
- ibuprofen [MeSH Descriptor]
- ibuprofen [MeSH concept]
Validated automatic mappings to BTNT
- ibuprofen [ATC Code]
- ibuprofen [ATC Code]
- ibuprofen [ATC Code]
- ibuprofen [ATC Code]
- ibuprofen [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 2C9 [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
has_target
- Prostaglandin G/H Synthase 1 [NCIt concept]
- Prostaglandin G/H Synthase 2 [NCIt concept]

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