Cadherin EGF LAG Seven-Pass G-Type Receptor 1

Preferred Label : Cadherin EGF LAG Seven-Pass G-Type Receptor 1;

NCIt synonyms : CELSR1; Protocadherin Flamingo-2 Protein; Protocadherin Flamingo 2; hFmi2; Flamingo Homolog 2; Adhesion G Protein-Coupled Receptor C1; Cadherin Family Member 9;

NCIt definition : Cadherin EGF LAG seven-pass G-type receptor 1 (3014 aa, 329 kDa) is encoded by the human CELSR1 gene. This protein is involved in cell-cell signaling and adhesion.;

NCIt note : Cadherin EGF LAG Seven-Pass G-Type Receptor 1, encoded by the human CELSR1 gene, is a G-Protein Coupled Receptor that may have an important role in cell/cell signaling during nervous system formation. It is an integral membrane protein with seven transmembrane domains, multiple cadherin repeats, EGF-like repeats, and laminin A G-type repeats. Two isoforms (1 and 2) may be produced by alternative splicing. The CELSR1 gene is developmentally regulated and neural-specific and the protein plays an unspecified role in early embryogenesis.;

Details

Origin ID

C25905;

UMLS CUI

C1122325;

OMIM relation
- Cadherin egf lag seven-pass g-type receptor 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- CELSR1 cadherin, human [MeSH concept]
- CELSR1 cadherin, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- CELSR1 Gene [NCIt concept]
- Cell Adhesion Molecule Gene [NCIt concept]
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Calcium Binding Protein [NCIt concept]
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cadherin Domain [NCIt concept]
- EGF-Like Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_biomarker_type
- Cluster of Differentiation [NCIt concept]
gene_product_is_element_in_pathway
- Bioactive Peptide Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Calcium Binding [NCIt concept]
- Cell Adhesion Process [NCIt concept]
- Cell-Cell Adhesion Process [NCIt concept]
- Embryogenesis [NCIt concept]
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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