Low-Density Lipoprotein Receptor-Related Protein 5

Preferred Label : Low-Density Lipoprotein Receptor-Related Protein 5;

NCIt synonyms : LRP-5;

NCIt definition : Low-density lipoprotein receptor-related protein 5 (1615 aa, 179 kDa) is encoded by the human LRP5 gene. This protein is involved in ligand binding, endocytosis and downstream Wnt signaling.;

Details

Origin ID

C95414;

UMLS CUI

C1313729;

Currated CISMeF NLP mapping
- low density lipoprotein Receptor-Related Protein-5 [MeSH Descriptor]
- low density lipoprotein Receptor-Related Protein-5 [MeSH concept]
OMIM relation
- Low density lipoprotein receptor-related protein 5 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- LRP5 protein, human [MeSH concept]
- LRP5 protein, human [MeSH Supplementary Concept]
- low density lipoprotein Receptor-Related Protein-5 [MeSH concept]
- low density lipoprotein Receptor-Related Protein-5 [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- LRP5 Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_biochemical_function
- Signaling Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- EGF-Like Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- N-Cadherin Signaling Pathway [NCIt concept]
- Wnt Signaling Pathway KEGG [NCIt concept]
- Wnt Signaling Pathway PID [NCIt concept]
gene_product_plays_role_in_biological_process
- Cholesterol Homeostasis [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Mediated Endocytosis [NCIt concept]
- Receptor Signaling [NCIt concept]
is_target
- LRP5 Antagonist BI 905681 [NCIt concept]

Keyword's position in hierarchy(ies) :

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