Protocadherin Fat 1

Preferred Label : Protocadherin Fat 1;

NCIt synonyms : FAT; Cadherin ME5; Cadherin-Related Tumor Suppressor; Cadherin Family Member 7; Protein Fat Homolog; Cadherin-Related Tumor Suppressor Homolog; FAT Tumor Suppressor 1; Cadherin-Related Family Member 8; FAT Protein; FAT Tumor Suppressor Homolog 1; FAT1;

NCIt definition : Protocadherin Fat 1 (4588 aa, 506 kDa) is encoded by the human FAT1 gene. This protein is involved in both cell-cell adhesion and cellular polarization.;

NCIt note : Protocadherin Fat 1 undergoes proteolytic cleavage; the extracellular domain is cleaved off and the cytoplasmic domain is transported into the nucleus. (UniProt);

Details

Origin ID

C17492;

UMLS CUI

C1435181;

False automatic mappings
- Fat (substance) [SNOMED CT concept]
- fats [MeSH Descriptor]
OMIM relation
- Fat atypical cadherin 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- FAT1 protein, human [MeSH concept]
- FAT1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cell Adhesion Molecule Gene [NCIt concept]
- FAT1 Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cadherin [NCIt concept]
- Calcium Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cadherin Domain [NCIt concept]
- EGF-Like Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_biomarker_type
- Cluster of Differentiation [NCIt concept]
gene_product_plays_role_in_biological_process
- Calcium Binding [NCIt concept]
- Cell Adhesion Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Morphogenesis [NCIt concept]

Keyword's position in hierarchy(ies) :

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