Cadherin - CISMeF

Preferred Label : Cadherin;

NCIt definition : The cadherins are transmembrane glycoproteins involved in calcium dependent specific cell-cell adhesion through homophilic binding. They are crucial for morphogenesis and synapse formation, but also are involved in tumor invasion. The classical cadherins have five homologous extracellular domains and a cytosolic domain which binds through catenin to the cytoskeleton. The extracellular domains are immunoglobulin-like beta-sandwiches comprising usually 7 strands in the two sheets.;

Details

Origin ID

C16373;

UMLS CUI

C0006631;

Automatic exact mappings (from CISMeF team)
- N-cadherin [FMA entity]
- P-cadherin [FMA entity]
- obsolete calcium-dependent cell adhesion molecule activity [GO term]
Biochemical function of gene products
- Protocadherin Alpha-C2 [NCIt concept]
- Protocadherin Fat 1 [NCIt concept]
- Protocadherin Fat 3 [NCIt concept]
- Protocadherin Fat 4 [NCIt concept]
- Protocadherin-16 [NCIt concept]
- Protocadherin-23 [NCIt concept]
- Protocadherin-7 [NCIt concept]
Currated CISMeF NLP mapping
- Cadherin [FMA entity]
- cadherins [MeSH Descriptor]
- cadherins [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Cadherin [FMA entity]
- cadherins [MeSH concept]
- cadherins [MeSH Descriptor]
gene_encodes_gene_product
- Cell Adhesion Molecule Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Calcium Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_biomarker_type
- Cluster of Differentiation [NCIt concept]
gene_product_plays_role_in_biological_process
- Calcium Binding [NCIt concept]
- Cell Adhesion Process [NCIt concept]
- Ligand Binding [NCIt concept]

Keyword's position in hierarchy(ies) :

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