Uromodulin - CISMeF

Preferred Label : Uromodulin;

NCIt synonyms : UMOD; Tamm-Horsfall Urinary Glycoprotein; THP; Tamm-Horsfall Glycoprotein;

NCIt definition : Uromodulin (640 aa, 70 kDa) is encoded by the human UMOD gene. This protein plays a role in the formation of the ascending limb of Henle, urine-concentrating ability and host defensive responses in the kidney.;

NCIt note : Uromodulin is a GPI-anchored protein that is post-translationally, proteolytically cleaved by hepsin at a conserved C-terminal proteolytic cleavage site to generate the secreted form found in urine.;

Details

Origin ID

C213455;

OMIM relation
- Uromodulin [OMIM gene]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- Transport Protein Gene [NCIt concept]
- UMOD Gene [NCIt concept]
gene_product_expressed_in_tissue
- Renal Tissue [NCIt concept]
- Renal Tubule Epithelium [NCIt concept]
gene_product_has_associated_anatomy
- Ascending Limb of Henle's Loop [NCIt concept]
- Cellular Membrane [NCIt concept]
- Distal Convoluted Tubule [NCIt concept]
- Extracellular Space [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_structural_domain_or_motif
- EGF-Like Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Homeostatic Process [NCIt concept]
- Immunity [NCIt concept]
- Ligand Binding [NCIt concept]
- Renal and Urologic Process [NCIt concept]
- Transport Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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